DSIP 10mg
DSIP 10mg ā DSIP 10mg
DSIP 10mg
$15.00 Original price was: $15.00.$8.00Current price is: $8.00.
DSIP 10mg
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DSIP 10mg
DSIP 10mg (Delta Sleep-Inducing Peptide) is a synthetic neuropeptide widely utilized in laboratory research focused on sleep regulation, neuroendocrine signaling, and circadian rhythm modulation. Originally isolated in studies examining natural sleep-promoting compounds, DSIP has been structurally replicated for controlled scientific investigation. DSIP 10mg is commonly supplied in lyophilized powder form, allowing researchers to preserve peptide stability and molecular integrity prior to reconstitution. In experimental environments, DSIP 10mg is selected for studies exploring sleep architecture, stress response pathways, and central nervous system regulatory mechanisms.
DSIP 10mg is primarily studied for its interaction with hypothalamic and pituitary pathways involved in sleep cycles and hormonal balance. Research indicates that DSIP may influence the modulation of corticotropin, luteinizing hormone, and growth hormone release under controlled conditions. Because of its potential regulatory role in neuroendocrine communication, DSIP 10mg is frequently incorporated into laboratory models investigating circadian rhythm disorders, stress adaptation, and neurotransmitter balance. Scientists examining sleep-stage distribution and REM/NREM transitions often utilize DSIP 10mg to evaluate peptide-mediated signaling effects within structured experimental frameworks.
From a biochemical perspective, DSIP 10mg is a small peptide composed of nine amino acids, enabling efficient receptor interaction and rapid systemic distribution in research models. Its relatively short half-life makes it particularly useful for studies requiring acute observation of neurochemical responses rather than prolonged systemic exposure. DSIP 10mg is often examined in relation to GABAergic signaling, cortisol regulation, and central nervous system stress markers. In controlled laboratory investigations, researchers analyze how DSIP 10mg may contribute to modulation of sleep latency, total sleep duration, and recovery-related biological processes.
Each vial of DSIP 10mg is typically manufactured under strict quality assurance protocols to ensure high purity and batch consistency. Analytical verification methods such as High-Performance Liquid Chromatography (HPLC) and mass spectrometry are commonly used to confirm peptide identity, molecular weight, and purity levels. Proper storage conditions, including refrigeration and protection from light and moisture, are essential for maintaining the structural stability of DSIP 10mg after reconstitution. Maintaining optimal handling procedures helps preserve experimental accuracy and reproducibility in laboratory settings.
DSIP 10mg is intended strictly for research use only and is not approved for human consumption or clinical application. Within scientific research environments, DSIP 10mg serves as a valuable tool for investigating sleep regulation mechanisms, neuroendocrine modulation, and stress-related hormonal pathways. By incorporating DSIP 10mg into structured laboratory protocols, researchers can explore the complex interactions between peptide signaling, circadian biology, and central nervous system function in a controlled and regulated setting.
| Product Name: | DSIP 10mg |
| Ā Unit size: | 10 mg/vial |
| Ā CAS NO.: | |
| Ā Synonyms: | |
| Ā Sequence: | |
| Ā Purity: | ā„99% (HPLC) |
| Ā Physical State: | Lyophilized Powder |
| Ā Solubility: | Soluble in water or 1% acetic acid |
| Ā Storage: | Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18Ā°C. Upon reconstitution of the peptide it should be stored at 4Ā°C between 2-21 days and for future use below -18Ā°C. |
DSIP (Delta Sleep-Inducing Peptide) ā High-Purity Laboratory Peptide (ā„99% HPLC) ā Manufactured by HPS
Product Overview
- Product Name: DSIP (Delta Sleep-Inducing Peptide)
- CAS Number: 62568-57-4
- Molecular Formula: C35H48N10O15
- Molecular Weight: 848.81 g/mol
- Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- Synonyms: Delta Sleep-Inducing Peptide, DSIP peptide
- Manufacturer: HPS (High Purity Science)
- Purity: ā„99% (Verified by High-Performance Liquid Chromatography – HPLC)
- Form: Lyophilized white powder
- Packaging: Pharmaceutical-grade research vial
- Intended Use: For laboratory research only, not for human or veterinary use
Introduction to DSIP
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide first isolated from the brains of rabbits in 1977. It has been extensively studied for its role in sleep regulation, modulation of biological rhythms, and neuroendocrine regulation. Its structure consists of nine amino acids, making it a nonapeptide with notable neuromodulatory and regulatory properties.
This synthetic version of DSIP, produced by HPS (High Purity Science), is manufactured under rigorous laboratory conditions, ensuring ā„99% purity confirmed by HPLC analysis. It is formulated specifically for scientific research, allowing researchers to explore its physiological, biochemical, and neurobiological effects with high reproducibility and reliability.
Key Features
- High Purity: ā„99% confirmed by HPLC
- Pharmaceutical-grade lyophilization for long-term stability
- Reliable sourcing from HPS, a reputed manufacturer of research-grade peptides
- Strict quality assurance and batch traceability
- Intended solely for in vitro and preclinical laboratory research
Biological Significance
DSIP plays a crucial role in several physiological and neurological processes:
1. Sleep Regulation
The peptide was originally identified for its sleep-promoting effects, particularly its ability to induce slow-wave sleep (SWS) without affecting rapid eye movement (REM) phases. Research has shown that DSIP may modulate the release of neurotransmitters involved in sleep architecture, including serotonin and norepinephrine.
2. Endocrine Regulation
DSIP appears to influence the secretion of several hormones, such as:
- Corticotropin (ACTH)
- Luteinizing hormone (LH)
- Growth hormone (GH)
Studies have suggested its involvement in hypothalamic-pituitary axis regulation.
3. Stress Modulation
DSIP has been observed to reduce corticosterone levels, suggesting a role in stress mitigation and anti-anxiety behavior in animal models. This effect may relate to its modulation of the GABAergic and serotonergic systems.
4. Pain Perception
Research has also explored DSIPās influence on analgesia. It may have a modulatory effect on opioid receptor systems, potentially enhancing or reducing pain thresholds under certain conditions.
5. Thermoregulation and Circadian Rhythms
DSIP is believed to affect thermoregulation, body temperature, and biological rhythms, making it a subject of interest in chronobiology and chronotherapy.
Research Applications
Because of its broad physiological influence, DSIP is studied in various research areas:
| Research Area | Focus |
|---|---|
| Neuroscience | Sleep cycles, neurotransmission, pain modulation |
| Endocrinology | Hormonal balance, growth hormone modulation |
| Psychopharmacology | Stress, anxiety, depression models |
| Chronobiology | Circadian rhythm, biological clock studies |
| Immunology | Interaction with immune responses and cytokine regulation |
| Metabolic Research | Potential link to metabolic rate and energy homeostasis |
Manufacturing and Quality Control by HPS
HPS (High Purity Science) follows stringent Good Manufacturing Practices (GMP) for peptide synthesis. All batches of DSIP are produced under sterile, temperature-controlled conditions using solid-phase peptide synthesis (SPPS). The peptide undergoes several purification stages and is verified for ā„99% purity using High-Performance Liquid Chromatography (HPLC).
Quality Parameters:
- Purity (HPLC): ā„99%
- Endotoxin Level: <0.1 EU/mg
- Moisture Content: <6%
- Solubility: Soluble in water, dilute acetic acid, or DMSO
- Appearance: White, lyophilized powder
- Storage Temperature: -20Ā°C for long-term storage
All products include a Certificate of Analysis (COA) for quality verification, batch number tracking, and expiration date.
HPLC Analysis (Summary)
Each batch of DSIP is analyzed via HPLC to ensure the consistency of peptide chain, purity, and absence of degradation or contamination. Hereās a typical HPLC profile summary (available in the accompanying COA file):
| Parameter | Value |
|---|---|
| Retention Time | 5.24 minutes |
| Peak Purity | ā„99.03% |
| Impurities Detected | <0.5% total (no major peaks) |
| Detection Wavelength | 220 nm |
This profile ensures research reliability and replicability.
Reconstitution & Storage Guidelines
Reconstitution:
DSIP should be reconstituted in sterile distilled water, 0.9% saline, or buffered solution (e.g., PBS) before use in research. Concentration should be adjusted based on experimental design.
Storage:
- Lyophilized Form: Stable at -20Ā°C for ā„24 months.
- After Reconstitution: Store at 2-8Ā°C and use within 7ā14 days.
- Avoid repeated freeze-thaw cycles to preserve peptide structure.
Packaging Options
HPS provides DSIP in:
- 1 mg vial
- 2 mg vial
- 5 mg vial
- Custom bulk orders available upon request
All vials are sealed in light-resistant, nitrogen-flushed containers, vacuum packed to preserve stability and purity.
Legal and Safety Disclaimer
This product is strictly intended for laboratory and scientific research. It is not approved for diagnostic, therapeutic, or human consumption purposes. Misuse of DSIP outside of approved research protocols may be subject to legal penalties.
Personal Protective Equipment (PPE) should be used when handling DSIP in any form, including gloves, lab coats, and eye protection. Use within a certified laboratory environment under guidance from qualified personnel.
Why Choose HPS for Peptides?
HPS (High Purity Science) is a trusted name in peptide production, with a focus on purity, quality assurance, and consistency across all batches. Researchers around the globe rely on HPS for their:
- ISO 9001:2015 certified manufacturing protocols
- Full-spectrum analytical documentation (COA, HPLC, MS)
- Transparent sourcing and technical support
- Custom peptide development services
With HPS, researchers can expect reproducibility, batch integrity, and competitive pricingāmaking it a preferred source for academic institutions, biotech firms, and pharmacological labs.
Conclusion
DSIP (Delta Sleep-Inducing Peptide) represents a unique area of research within neurobiology, endocrinology, and sleep science. Manufactured by HPS with ā„99% HPLC purity, it ensures reliable performance in various preclinical research models.
By adhering to rigorous quality standards, HPS offers DSIP that is trusted, pure, and reproducibleābacked with full analytical documentation and research-grade packaging.
DSIP (Delta Sleep-Inducing Peptide) ā Hochreines Laborpeptid (ā„99āÆ% HPLC) ā Hergestellt von HPS
ProduktĆ¼bersicht
- Produktname: DSIP (Delta Sleep-Inducing Peptide)
- CAS-Nummer: 62568-57-4
- Molekularformel: Cāā HāāNāāOāā
- Molekulargewicht: 848.81 g/mol
- Sequenz: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- Synonyme: Delta Sleep-Inducing Peptid, DSIP-Peptid
- Hersteller: HPS (High Purity Science)
- Reinheit: ā„99āÆ% (bestƤtigt durch HochleistungsflĆ¼ssigkeitschromatographie ā HPLC)
- Form: Lyophilisiertes weiĆes Pulver
- Verpackung: ForschungsflƤschchen in pharmazeutischer QualitƤt
- Verwendungszweck: Nur fĆ¼r wissenschaftliche Forschung. Nicht zur Anwendung am Menschen oder Tier bestimmt.
EinfĆ¼hrung in DSIP
DSIP (Delta Sleep-Inducing Peptide) ist ein natĆ¼rlich vorkommendes Neuropeptid, das erstmals 1977 aus den Gehirnen von Kaninchen isoliert wurde. Es wurde umfangreich im Hinblick auf seine Rolle bei der Schlafregulation, der Modulation biologischer Rhythmen und der neuroendokrinen Steuerung untersucht. Die Struktur besteht aus neun AminosƤuren und macht DSIP zu einem Nonapeptid mit bemerkenswerten neuromodulatorischen und regulatorischen Eigenschaften.
Die synthetische Version von DSIP, hergestellt von HPS (High Purity Science), wird unter strengen Laborbedingungen produziert, mit einer garantierten Reinheit von ā„99āÆ%, bestƤtigt durch HPLC. Diese Formulierung ist speziell fĆ¼r wissenschaftliche Studien entwickelt worden, um Forscher*innen eine verlƤssliche Grundlage fĆ¼r physiologische, biochemische und neurobiologische Experimente zu bieten.
Hauptmerkmale
- Hochreine QualitƤt: ā„99āÆ% Reinheit durch HPLC bestƤtigt
- Pharmazeutisch gefriergetrocknet zur langfristigen StabilitƤt
- VertrauenswĆ¼rdiger Hersteller (HPS) mit hoher Produktionskompetenz
- Strenge QualitƤtskontrollen und RĆ¼ckverfolgbarkeit jeder Charge
- AusschlieĆlich fĆ¼r In-vitro- und vorklinische Forschungszwecke
Biologische Bedeutung von DSIP
1. Schlafregulation:
DSIP wurde ursprĆ¼nglich wegen seiner schlaffƶrdernden Wirkung entdeckt, insbesondere durch die FƤhigkeit, den Tiefschlaf (Slow-Wave Sleep, SWS) zu induzieren, ohne die REM-Phasen zu beeintrƤchtigen. Es moduliert die AusschĆ¼ttung schlafrelevanter Neurotransmitter wie Serotonin und Noradrenalin.
2. Endokrine Regulation:
DSIP beeinflusst die Sekretion mehrerer Hormone, darunter:
- Corticotropin (ACTH)
- Luteinisierendes Hormon (LH)
- Wachstumshormon (GH)
Diese Effekte stehen im Zusammenhang mit der Hypothalamus-Hypophysen-Achse.
3. Stressmodulation:
In Tiermodellen reduziert DSIP die Corticosteronspiegel und zeigt anxiolytische (angstlƶsende) Eigenschaften, wahrscheinlich Ć¼ber die GABAergen und serotonergen Systeme.
4. Schmerzwahrnehmung:
DSIP beeinflusst mƶglicherweise das Schmerzempfinden durch seine Wechselwirkungen mit Opioidrezeptoren.
5. Thermoregulation und zirkadiane Rhythmen:
DSIP scheint Kƶrpertemperatur und biologische Rhythmen zu beeinflussen, was es zu einem interessanten Forschungsobjekt in der Chronobiologie macht.
Forschungsanwendungen
| Forschungsfeld | Fokus |
|---|---|
| Neurowissenschaften | Schlafzyklen, Neurotransmission, Schmerzmodulation |
| Endokrinologie | Hormonhaushalt, WachstumshormonaktivitƤt |
| Psychopharmakologie | Stress, Angst, Depression |
| Chronobiologie | Zirkadiane Rhythmen, biologische Uhren |
| Immunologie | Einfluss auf Immunantworten und Zytokinregulation |
| Stoffwechselforschung | Zusammenhang mit Energiehaushalt und Stoffwechselrate |
Herstellung & QualitƤtskontrolle durch HPS
HPS (High Purity Science) wendet strenge GMP-Richtlinien (Good Manufacturing Practice) bei der Peptidsynthese an. DSIP wird durch Festphasenpeptidsynthese (SPPS) unter sterilen Bedingungen hergestellt, mehrfach gereinigt und auf Reinheit von ā„99āÆ% per HPLC getestet.
QualitƤtsparameter:
- HPLC-Reinheit: ā„99āÆ%
- Endotoxingehalt: <0,1 EU/mg
- Feuchtigkeitsgehalt: <6āÆ%
- Lƶslichkeit: In Wasser, verdĆ¼nnter EssigsƤure oder DMSO lƶslich
- Erscheinungsbild: WeiĆes lyophilisiertes Pulver
- Lagerung: -20āÆĀ°C fĆ¼r Langzeitlagerung empfohlen
Jede Charge wird mit einem Analysezertifikat (COA) ausgeliefert, inklusive Chargennummer, Verfallsdatum und HPLC-Daten.
HPLC-Analyse (Zusammenfassung)
Jede Charge DSIP wird mittels HPLC auf Konsistenz, Reinheit und eventuelle Verunreinigungen geprĆ¼ft. Beispielprofil:
| Parameter | Wert |
|---|---|
| Retentionszeit | 5,24 Minuten |
| Peak-Reinheit | ā„99,03āÆ% |
| Gesamtverunreinigungen | <0,5āÆ% |
| DetektionswellenlƤnge | 220 nm |
Dieses Profil sichert Reproduzierbarkeit und ValiditƤt fĆ¼r wissenschaftliche Studien.
Rekonstitution & Lagerung
Rekonstitution:
DSIP sollte in sterilem Wasser, 0,9āÆ% Kochsalzlƶsung oder einem geeigneten Puffer (z.āÆB. PBS) gelƶst werden. Die Konzentration richtet sich nach dem Versuchsprotokoll.
Lagerung:
- Lyophilisierte Form: Stabil bei -20āÆĀ°C fĆ¼r mindestens 24 Monate
- Nach Rekonstitution: 2ā8āÆĀ°C, innerhalb von 7ā14 Tagen verbrauchen
- Hinweis: Wiederholtes Einfrieren und Auftauen vermeiden
Verpackungsoptionen
VerfĆ¼gbar in den folgenden Mengen:
- 1 mg Vial
- 2 mg Vial
- 5 mg Vial
- Individuelle GroĆbestellungen auf Anfrage mƶglich
Alle Vials werden lichtgeschĆ¼tzt, vakuumversiegelt und unter StickstoffatmosphƤre geliefert.
Rechtlicher Hinweis & Sicherheit
Dieses Produkt ist ausschlieĆlich fĆ¼r wissenschaftliche Laborforschung vorgesehen. Es ist nicht fĆ¼r diagnostische oder therapeutische Anwendungen beim Menschen oder Tier zugelassen. Jeglicher Missbrauch kann rechtliche Konsequenzen nach sich ziehen.
SicherheitsausrĆ¼stung (PSA) wie Laborkittel, Handschuhe und Schutzbrille ist beim Umgang mit DSIP erforderlich. Nur in zugelassenen Laboren unter Aufsicht qualifizierter FachkrƤfte verwenden.
Warum DSIP von HPS wƤhlen?
HPS (High Purity Science) ist bekannt fĆ¼r:
- ISO 9001:2015-zertifizierte Herstellungsverfahren
- VollstƤndige analytische Dokumentation (COA, HPLC, MS)
- Transparente Lieferketten & technischen Support
- MaĆgeschneiderte Peptidsynthese fĆ¼r Forschungseinrichtungen
Forschende weltweit vertrauen auf HPS wegen der hohen QualitƤt, gleichbleibenden Reinheit und zuverlƤssigen Lieferung.
Fazit
DSIP (Delta Sleep-Inducing Peptide) stellt ein faszinierendes Forschungsfeld dar ā insbesondere in den Bereichen Neurobiologie, Endokrinologie und Schlafwissenschaften. Die von HPS hergestellte Version mit ā„99āÆ% HPLC-geprĆ¼fter Reinheit garantiert zuverlƤssige Resultate in vorklinischen Studien.
Dank rigoroser QualitƤtskontrollen, transparenter Analytik und forschungsgerechter Verpackung ist DSIP von HPS eine exzellente Wahl fĆ¼r moderne Labore und akademische Institutionen.
DSIP (Peptide Inducteur du Sommeil Delta) ā Peptide de Recherche de Haute PuretĆ© (ā„99āÆ% HPLC) ā FabriquĆ© par HPS
PrƩsentation du Produit
- Nom du produit : DSIP (Peptide Inducteur du Sommeil Delta)
- NumƩro CAS : 62568-57-4
- Formule molĆ©culaire : Cāā HāāNāāOāā
- Masse molƩculaire : 848,81 g/mol
- SĆ©quence : Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- Synonymes : Peptide inducteur du sommeil delta, peptide DSIP
- Fabricant : HPS (High Purity Science)
- PuretĆ© : ā„99āÆ% (vĆ©rifiĆ©e par chromatographie liquide haute performance – HPLC)
- Forme : Poudre blanche lyophilisƩe
- Conditionnement : Flacon de qualitƩ pharmaceutique pour recherche
- Utilisation prĆ©vue : Ć usage exclusivement en recherche scientifique, non destinĆ© Ć un usage humain ou vĆ©tĆ©rinaire
Introduction au DSIP
Le DSIP (Delta Sleep-Inducing Peptide) est un neuropeptide naturellement prĆ©sent, isolĆ© pour la premiĆØre fois dans les annĆ©es 1970 Ć partir du cerveau de lapins. Il est reconnu pour son rĆ“le dans la rĆ©gulation du sommeil, les rythmes biologiques et lāĆ©quilibre neuroendocrinien. ComposĆ© de neuf acides aminĆ©s, cāest un nonapeptide possĆ©dant des propriĆ©tĆ©s neuromodulatrices remarquables.
La version synthĆ©tique de DSIP produite par HPS (High Purity Science) est Ć©laborĆ©e selon des conditions de laboratoire strictes, assurant une puretĆ© ā„99āÆ%, confirmĆ©e par analyse HPLC. Elle est spĆ©cialement conƧue pour les laboratoires de recherche souhaitant Ć©tudier ses effets physiologiques, biochimiques et neurologiques avec prĆ©cision et fiabilitĆ©.
CaractƩristiques ClƩs
- PuretĆ© exceptionnelle : ā„99āÆ% vĆ©rifiĆ©e par HPLC
- Lyophilisation de qualitƩ pharmaceutique pour une meilleure stabilitƩ
- Fournisseur de confiance (HPS), spƩcialisƩ dans les peptides de laboratoire
- ContrƓle qualitƩ strict avec traƧabilitƩ des lots
- RĆ©servĆ© exclusivement Ć la recherche in vitro et prĆ©clinique
Importance Biologique du DSIP
1. RĆ©gulation du sommeil
Le DSIP est reconnu pour ses effets inducteurs du sommeil profond (sommeil Ć ondes lentes – SWS), sans perturber les phases REM. Il agirait en modulant les neurotransmetteurs impliquĆ©s dans lāarchitecture du sommeil, tels que la sĆ©rotonine et la noradrĆ©naline.
2. RĆ©gulation endocrinienne
Le DSIP influence la sƩcrƩtion de plusieurs hormones :
- Corticotrophine (ACTH)
- Hormone lutƩinisante (LH)
- Hormone de croissance (GH)
Son action semble liĆ©e Ć lāaxe hypothalamo-hypophysaire.
3. Modulation du stress
Chez les animaux, il rĆ©duit les taux de corticostĆ©rone, suggĆ©rant une activitĆ© anxiolytique et anti-stress, probablement via les systĆØmes GABAergique et sĆ©rotoninergique.
4. Perception de la douleur
Des Ć©tudes suggĆØrent que le DSIP pourrait avoir un effet modulateur sur les rĆ©cepteurs opioĆÆdes, influenƧant la sensibilitĆ© Ć la douleur.
5. ThermorƩgulation et rythmes circadiens
Le DSIP est Ć©galement impliquĆ© dans la rĆ©gulation de la tempĆ©rature corporelle et des rythmes biologiques, ce qui en fait un sujet dāintĆ©rĆŖt en chronobiologie.
Applications en Recherche
| Domaine de recherche | Objet dāĆ©tude |
|---|---|
| Neurosciences | Sommeil, neurotransmission, modulation de la douleur |
| Endocrinologie | SƩcrƩtion hormonale, axe H-H, hormone de croissance |
| Psychopharmacologie | Stress, anxiƩtƩ, dƩpression |
| Chronobiologie | Rythmes biologiques, sommeil et horloge interne |
| Immunologie | RƩponse immunitaire, rƩgulation des cytokines |
| Recherche mƩtabolique | Taux mƩtabolique, Ʃnergie et homƩostasie |
Fabrication & ContrƓle QualitƩ par HPS
HPS (High Purity Science) applique des Bonnes Pratiques de Fabrication (GMP) strictes pour la synthĆØse de peptides. Le DSIP est fabriquĆ© par synthĆØse peptidique en phase solide (SPPS) dans des conditions stĆ©riles, contrĆ“lĆ©es en tempĆ©rature. Chaque lot est purifiĆ© et analysĆ© via HPLC pour garantir une puretĆ© de ā„99āÆ%.
ParamĆØtres de qualitĆ© :
- PuretĆ© (HPLC) : ā„99āÆ%
- Endotoxines : <0,1āÆEU/mg
- Teneur en eau : <6āÆ%
- SolubilitĆ© : Soluble dans lāeau, lāacide acĆ©tique diluĆ© ou le DMSO
- Aspect : Poudre blanche lyophilisƩe
- Conservation : -20āÆĀ°C pour stockage longue durĆ©e
Un certificat dāanalyse (COA) est fourni avec chaque lot, incluant le numĆ©ro de lot, la date de pĆ©remption et les donnĆ©es HPLC.
Analyse HPLC (RƩsumƩ)
Chaque lot est contrĆ“lĆ© par HPLC pour vĆ©rifier l’intĆ©gritĆ© de la chaĆ®ne peptidique, la puretĆ©, et l’absence d’impuretĆ©s ou de dĆ©gradation.
| ParamĆØtre | Valeur |
|---|---|
| Temps de rƩtention | 5,24 minutes |
| PuretĆ© du pic | ā„99,03āÆ% |
| ImpuretĆ©s dĆ©tectĆ©es | <0,5āÆ% |
| Longueur dāonde de dĆ©tection | 220 nm |
Ces rƩsultats garantissent des conditions optimales pour des recherches reproductibles.
Instructions de Reconstitution & Stockage
Reconstitution :
Dissoudre le DSIP dans de lāeau stĆ©rile, une solution saline Ć 0,9āÆ% ou un tampon appropriĆ© (ex. PBS). La concentration doit ĆŖtre adaptĆ©e au protocole expĆ©rimental.
Stockage :
- Poudre lyophilisĆ©e : Stable Ć -20āÆĀ°C pendant ā„24 mois
- AprĆØs reconstitution : Conserver entre 2ā8āÆĀ°C, Ć utiliser dans un dĆ©lai de 7ā14 jours
- Important : Ćviter les cycles rĆ©pĆ©tĆ©s de congĆ©lation/dĆ©congĆ©lation
Options de Conditionnement
Disponible en flacons de :
- 1 mg
- 2 mg
- 5 mg
- Commandes en vrac personnalisƩes sur demande
Les flacons sont scellĆ©s sous atmosphĆØre dāazote, protĆ©gĆ©s de la lumiĆØre, et conditionnĆ©s sous vide pour prĆ©server la stabilitĆ©.
Avis LƩgal & SƩcuritƩ
Ce produit est strictement rĆ©servĆ© Ć la recherche scientifique. Il nāest pas destinĆ© Ć un usage mĆ©dical ou vĆ©tĆ©rinaire, ni Ć la consommation humaine. Toute utilisation hors cadre rĆ©glementĆ© peut entraĆ®ner des sanctions.
Ćquipement de protection individuelle (EPI) obligatoire : gants, blouse de laboratoire et lunettes de sĆ©curitĆ©. Utiliser uniquement en environnement de laboratoire certifiĆ©, sous supervision professionnelle.
Pourquoi Choisir les Peptides de HPS ?
HPS (High Purity Science) est reconnu pour :
- Son protocole de fabrication certifiƩ ISO 9001:2015
- Une documentation analytique complĆØte (COA, HPLC, spectromĆ©trie de masse)
- Une traƧabilitƩ totale et un support technique rƩactif
- Des services personnalisƩs pour le dƩveloppement de peptides sur mesure
Les laboratoires acadĆ©miques, cliniques et pharmaceutiques du monde entier font confiance Ć HPS pour leur engagement en matiĆØre de qualitĆ©, de reproductibilitĆ© et de transparence.
Conclusion
Le DSIP (Peptide Inducteur du Sommeil Delta) est un outil de recherche prometteur en neurobiologie, endocrinologie et sciences du sommeil. FabriquĆ© par HPS avec une puretĆ© ā„99āÆ%, il offre une fiabilitĆ© exceptionnelle pour des modĆØles expĆ©rimentaux prĆ©cliniques.
GrĆ¢ce Ć ses normes de qualitĆ© rigoureuses, sa documentation analytique complĆØte et son conditionnement professionnel, le DSIP dāHPS est un choix de confiance pour toute Ć©quipe de recherche scientifique.
DSIP (PĆ©ptido Inductor del SueƱo Delta) ā PĆ©ptido de InvestigaciĆ³n de Alta Pureza (ā„99āÆ% HPLC) ā Fabricado por HPS
Resumen del Producto
- Nombre del producto: DSIP (Delta Sleep-Inducing Peptide)
- NĆŗmero CAS: 62568-57-4
- FĆ³rmula molecular: Cāā HāāNāāOāā
- Peso molecular: 848.81 g/mol
- Secuencia: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- SinĆ³nimos: PĆ©ptido inductor del sueƱo delta, pĆ©ptido DSIP
- Fabricante: HPS (High Purity Science)
- Pureza: ā„99āÆ% (verificada por cromatografĆa lĆquida de alta resoluciĆ³n ā HPLC)
- Forma: Polvo blanco liofilizado
- Envase: Vial de calidad farmacĆ©utica para investigaciĆ³n
- Uso previsto: Solo para investigaciĆ³n cientĆfica, no para uso humano ni veterinario
IntroducciĆ³n al DSIP
El DSIP (PĆ©ptido Inductor del SueƱo Delta) es un neuropĆ©ptido natural identificado por primera vez en cerebros de conejos en 1977. Ha sido ampliamente estudiado por su papel en la regulaciĆ³n del sueƱo, los ritmos biolĆ³gicos y el control neuroendocrino. EstĆ” compuesto por nueve aminoĆ”cidos, lo que lo convierte en un nonapĆ©ptido con propiedades neuromoduladoras y reguladoras notables.
La versiĆ³n sintĆ©tica de DSIP, producida por HPS, se fabrica bajo condiciones de laboratorio estrictas, garantizando una pureza ā„99āÆ% confirmada por HPLC. EstĆ” formulado especĆficamente para estudios cientĆficos que buscan explorar sus efectos fisiolĆ³gicos, bioquĆmicos y neurolĆ³gicos con gran confiabilidad y reproducibilidad.
CaracterĆsticas Principales
- Alta pureza: ā„99āÆ% verificada por HPLC
- LiofilizaciĆ³n de calidad farmacĆ©utica para mayor estabilidad
- Proveedor confiable (HPS) especializado en pƩptidos de laboratorio
- Control de calidad riguroso y trazabilidad por lote
- Uso exclusivo para investigaciĆ³n in vitro y preclĆnica
Importancia BiolĆ³gica del DSIP
1. RegulaciĆ³n del sueƱo
El DSIP fue identificado por su capacidad para inducir el sueƱo profundo (sueƱo de ondas lentas – SWS) sin alterar las fases REM. Se cree que modula neurotransmisores clave en la arquitectura del sueƱo, como la serotonina y la noradrenalina.
2. RegulaciĆ³n endocrina
El DSIP influye en la secreciĆ³n de varias hormonas, entre ellas:
- Corticotropina (ACTH)
- Hormona luteinizante (LH)
- Hormona del crecimiento (GH)
Se ha sugerido que participa en la regulaciĆ³n del eje hipotĆ”lamo-hipĆ³fisis.
3. ModulaciĆ³n del estrĆ©s
En modelos animales, el DSIP reduce los niveles de corticosterona, lo que indica un posible efecto ansiolĆtico y anti-estrĆ©s, probablemente a travĆ©s de los sistemas GABAĆ©rgico y serotoninĆ©rgico.
4. PercepciĆ³n del dolor
La investigaciĆ³n indica que el DSIP podrĆa modular la sensibilidad al dolor a travĆ©s de los receptores opioides.
5. TermorregulaciĆ³n y ritmos circadianos
TambiĆ©n se ha implicado al DSIP en la regulaciĆ³n de la temperatura corporal y los ritmos biolĆ³gicos, lo que lo convierte en un objeto de estudio relevante en cronobiologĆa.
Aplicaciones en InvestigaciĆ³n
| Ćrea de investigaciĆ³n | Foco de estudio |
|---|---|
| Neurociencia | Ciclos del sueƱo, neurotransmisiĆ³n, dolor |
| EndocrinologĆa | Balance hormonal, eje H-H, hormona del crecimiento |
| PsicofarmacologĆa | EstrĆ©s, ansiedad, depresiĆ³n |
| CronobiologĆa | Ritmos circadianos, reloj biolĆ³gico |
| InmunologĆa | Respuestas inmunitarias, regulaciĆ³n de citoquinas |
| InvestigaciĆ³n metabĆ³lica | Tasa metabĆ³lica, equilibrio energĆ©tico |
FabricaciĆ³n y Control de Calidad por HPS
HPS (High Purity Science) emplea estrictas Buenas PrĆ”cticas de Manufactura (GMP) en la sĆntesis de pĆ©ptidos. El DSIP es fabricado mediante sĆntesis de pĆ©ptido en fase sĆ³lida (SPPS), en condiciones estĆ©riles y controladas. Cada lote es purificado y evaluado mediante HPLC, garantizando una pureza de ā„99āÆ%.
ParƔmetros de calidad:
- Pureza (HPLC): ā„99āÆ%
- Nivel de endotoxinas: <0.1 EU/mg
- Contenido de humedad: <6āÆ%
- Solubilidad: Soluble en agua, Ɣcido acƩtico diluido o DMSO
- Apariencia: Polvo blanco liofilizado
- Almacenamiento: -20āÆĀ°C para almacenamiento a largo plazo
Se proporciona un Certificado de AnĆ”lisis (COA) con cada lote, con nĆŗmero de lote, fecha de caducidad y perfil HPLC.
AnƔlisis HPLC (Resumen)
Cada lote de DSIP se analiza por HPLC para asegurar la integridad de la cadena peptĆdica, la pureza y la ausencia de impurezas.
| ParƔmetro | Valor |
|---|---|
| Tiempo de retenciĆ³n | 5,24 minutos |
| Pureza del pico | ā„99,03āÆ% |
| Impurezas detectadas | <0,5āÆ% |
| Longitud de onda de detecciĆ³n | 220 nm |
Estos datos aseguran alta reproducibilidad y fiabilidad en investigaciĆ³n.
ReconstituciĆ³n y Almacenamiento
ReconstituciĆ³n:
Reconstituir en agua estĆ©ril, soluciĆ³n salina al 0,9āÆ% o un tampĆ³n como PBS. La concentraciĆ³n depende del protocolo experimental.
Almacenamiento:
- Forma liofilizada: Estable a -20āÆĀ°C durante ā„24 meses
- Tras reconstituciĆ³n: Conservar entre 2ā8āÆĀ°C, usar en 7ā14 dĆas
- Evitar ciclos repetidos de congelaciĆ³n y descongelaciĆ³n
Opciones de PresentaciĆ³n
Disponible en viales de:
- 1 mg
- 2 mg
- 5 mg
- Pedidos a granel personalizados disponibles bajo solicitud
Todos los viales se sellan en atmĆ³sfera de nitrĆ³geno, protegidos de la luz y empacados al vacĆo para preservar su estabilidad y pureza.
Aviso Legal y Seguridad
Este producto es exclusivamente para uso en investigaciĆ³n cientĆfica. No estĆ” aprobado para diagnĆ³stico, tratamiento ni consumo humano o veterinario. El mal uso fuera de los protocolos de investigaciĆ³n puede estar sujeto a sanciones legales.
Equipo de protecciĆ³n personal (EPP) obligatorio: guantes, bata de laboratorio y protecciĆ³n ocular. Solo debe ser manipulado en laboratorios certificados y bajo supervisiĆ³n de personal cualificado.
ĀæPor quĆ© elegir los pĆ©ptidos de HPS?
HPS (High Purity Science) es reconocido por:
- Protocolos de fabricaciĆ³n certificados ISO 9001:2015
- DocumentaciĆ³n analĆtica completa (COA, HPLC, espectrometrĆa de masas)
- Transparencia en la cadena de suministro y soporte tƩcnico especializado
- Servicios de desarrollo personalizado de pĆ©ptidos para investigaciĆ³n
Laboratorios acadĆ©micos, farmacĆ©uticos y biotecnolĆ³gicos de todo el mundo confĆan en HPS por su pureza, reproducibilidad y compromiso con la calidad.
ConclusiĆ³n
El DSIP (PĆ©ptido Inductor del SueƱo Delta) es un pĆ©ptido prometedor en los campos de la neurobiologĆa, endocrinologĆa y ciencia del sueƱo. Fabricado por HPS con una pureza de ā„99āÆ%, proporciona resultados fiables en modelos preclĆnicos de investigaciĆ³n.
Gracias a sus altos estĆ”ndares de calidad, documentaciĆ³n completa y presentaciĆ³n profesional, el DSIP de HPS es una opciĆ³n de confianza para instituciones cientĆficas en todo el mundo.
DSIP (Delta Sleep-Inducing Peptide) ā WysokoczystoÅciowy Peptyd Badawczy (ā„99% HPLC) ā Wyprodukowany przez HPS
Opis Produktu
- Nazwa produktu: DSIP (Delta Sleep-Inducing Peptide)
- Numer CAS: 62568-57-4
- WzĆ³r chemiczny: Cāā HāāNāāOāā
- Masa molowa: 848,81 g/mol
- Sekwencja: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- Synonimy: Delta Sleep-Inducing Peptide, peptyd DSIP
- Producent: HPS (High Purity Science)
- CzystoÅÄ: ā„99% (potwierdzona przez wysokosprawnÄ chromatografiÄ cieczowÄ ā HPLC)
- Forma: Liofilizowany biaÅy proszek
- Opakowanie: Fiolka badawcza klasy farmaceutycznej
- Przeznaczenie: WyÅÄ cznie do zastosowaÅ laboratoryjnych; nie do użytku u ludzi ani zwierzÄ t
Wprowadzenie do DSIP
DSIP (Delta Sleep-Inducing Peptide) to naturalnie wystÄpujÄ cy neuropeptyd po raz pierwszy wyizolowany z mĆ³zgĆ³w krĆ³likĆ³w w 1977 roku. Od tego czasu byÅ intensywnie badany pod kÄ tem roli w regulacji snu, rytmĆ³w biologicznych oraz funkcji neuroendokrynnych. SkÅada siÄ z dziewiÄciu aminokwasĆ³w, co czyni go nonapeptydem o istotnych wÅaÅciwoÅciach modulacyjnych.
Wersja syntetyczna DSIP produkowana przez HPS jest wytwarzana w rygorystycznych warunkach laboratoryjnych, z gwarantowanÄ czystoÅciÄ ā„99%, potwierdzonÄ analizÄ HPLC. Produkt ten zostaÅ zaprojektowany specjalnie do badaÅ naukowych, zapewniajÄ c wysokÄ powtarzalnoÅÄ i wiarygodnoÅÄ wynikĆ³w.
Kluczowe Cechy
- Wysoka czystoÅÄ: ā„99%, potwierdzona przez HPLC
- Liofilizacja klasy farmaceutycznej dla dÅugiej trwaÅoÅci
- Zaufany producent ā HPS, specjalizujÄ cy siÄ w peptydach badawczych
- Rygorystyczna kontrola jakoÅci i peÅna identyfikowalnoÅÄ partii
- Przeznaczony wyÅÄ cznie do badaÅ in vitro i przedklinicznych
Znaczenie Biologiczne DSIP
1. Regulacja snu
DSIP zostaÅ pierwotnie odkryty ze wzglÄdu na swoje wÅaÅciwoÅci wspomagajÄ
ce sen ā szczegĆ³lnie wpÅyw na fazÄ snu gÅÄbokiego (slow-wave sleep, SWS), bez zaburzania fazy REM. Peptyd ten może modulowaÄ neuroprzekaÅŗniki, takie jak serotonina i noradrenalina.
2. Regulacja hormonalna
DSIP wpÅywa na wydzielanie kilku ważnych hormonĆ³w:
- Kortykotropiny (ACTH)
- Hormonu luteinizujÄ cego (LH)
- Hormonu wzrostu (GH)
Może uczestniczyÄ w regulacji osi podwzgĆ³rzeāprzysadka.
3. Modulacja stresu
Badania na zwierzÄtach wykazaÅy, że DSIP obniża poziom kortykosteronu, co sugeruje jego dziaÅanie przeciwlÄkowe i antystresowe ā prawdopodobnie poprzez ukÅad GABAergiczny i serotoninergiczny.
4. Percepcja bĆ³lu
DSIP może modulowaÄ ukÅad receptorĆ³w opioidowych, wpÅywajÄ
c na prĆ³g odczuwania bĆ³lu.
5. Termoregulacja i rytmy dobowe
DSIP bierze udziaÅ w regulacji temperatury ciaÅa i rytmĆ³w okoÅodobowych, co czyni go interesujÄ
cym obiektem badaÅ w dziedzinie chronobiologii.
Zastosowania Badawcze
| Dziedzina badaÅ | Zakres badaÅ |
|---|---|
| Neurobiologia | Cykl snu, neurotransmisja, modulacja bĆ³lu |
| Endokrynologia | RĆ³wnowaga hormonalna, oÅ H-H, hormon wzrostu |
| Psychofarmakologia | Stres, lÄk, depresja |
| Chronobiologia | Rytmy dobowe, zegar biologiczny |
| Immunologia | Reakcje immunologiczne, regulacja cytokin |
| Badania metaboliczne | Tempo metabolizmu, rĆ³wnowaga energetyczna |
Produkcja i Kontrola JakoÅci przez HPS
HPS (High Purity Science) stosuje ÅcisÅe zasady Dobrej Praktyki Wytwarzania (GMP) przy syntezie peptydĆ³w. DSIP jest produkowany metodÄ syntezy peptydowej w fazie staÅej (SPPS) w warunkach sterylnych i kontrolowanych temperaturowo. Każda partia podlega oczyszczeniu i analizie metodÄ HPLC w celu zapewnienia czystoÅci ā„99%.
Parametry jakoÅciowe:
- CzystoÅÄ (HPLC): ā„99%
- Poziom endotoksyn: <0,1 EU/mg
- ZawartoÅÄ wilgoci: <6%
- RozpuszczalnoÅÄ: Rozpuszczalny w wodzie, rozcieÅczonym kwasie octowym lub DMSO
- WyglÄ d: BiaÅy, liofilizowany proszek
- Temperatura przechowywania: ā20āÆĀ°C (dÅugoterminowo)
Każdy produkt zawiera certyfikat analizy (COA), numer partii, datÄ ważnoÅci oraz profil HPLC.
Analiza HPLC (Podsumowanie)
Każda partia DSIP jest analizowana przez HPLC w celu potwierdzenia czystoÅci ÅaÅcucha peptydowego i wykrycia ewentualnych zanieczyszczeÅ.
| Parametr | WartoÅÄ |
|---|---|
| Czas retencji | 5,24 minuty |
| CzystoÅÄ piku | ā„99,03% |
| Wykryte zanieczyszczenia | <0,5% |
| DÅugoÅÄ fali detekcji | 220 nm |
Profil ten gwarantuje wiarygodnoÅÄ i powtarzalnoÅÄ badaÅ.
Rekonstytucja i Przechowywanie
Rekonstytucja:
DSIP należy rozpuÅciÄ w wodzie destylowanej (sterylnej), 0,9% roztworze soli fizjologicznej lub buforze (np. PBS). StÄżenie należy dostosowaÄ do projektu eksperymentu.
Przechowywanie:
- Forma liofilizowana: Stabilna przez ā„24 miesiÄ ce w ā20āÆĀ°C
- Po rekonstytucji: PrzechowywaÄ w temperaturze 2ā8āÆĀ°C i zużyÄ w ciÄ gu 7ā14 dni
- UnikaÄ cykli zamrażania i rozmrażania
Opcje Pakowania
DostÄpne opakowania:
- Fiolka 1 mg
- Fiolka 2 mg
- Fiolka 5 mg
- ZamĆ³wienia hurtowe na życzenie
Fiolki sÄ pakowane prĆ³Å¼niowo, zabezpieczone przed ÅwiatÅem i wypeÅnione azotem dla zachowania maksymalnej stabilnoÅci.
Informacje Prawne i BezpieczeÅstwo
Produkt przeznaczony wyÅÄ cznie do badaÅ naukowych. Nie dopuszczony do stosowania u ludzi ani zwierzÄ t. Wykorzystanie poza zatwierdzonymi protokoÅami badawczymi może prowadziÄ do konsekwencji prawnych.
Årodki ochrony osobistej (PPE), takie jak rÄkawiczki, fartuch laboratoryjny i okulary ochronne, sÄ wymagane podczas obsÅugi DSIP. UżywaÄ tylko w laboratorium pod nadzorem wykwalifikowanego personelu.
Dlaczego warto wybraÄ peptydy HPS?
HPS (High Purity Science) oferuje:
- Certyfikowane procedury produkcji (ISO 9001:2015)
- KompletnÄ dokumentacjÄ analitycznÄ (COA, HPLC, MS)
- PrzejrzystoÅÄ w ÅaÅcuchu dostaw i wsparcie techniczne
- UsÅugi niestandardowej syntezy peptydĆ³w na zamĆ³wienie
HPS cieszy siÄ zaufaniem laboratoriĆ³w naukowych, instytutĆ³w akademickich i firm biotechnologicznych na caÅym Åwiecie dziÄki najwyższej jakoÅci i niezawodnoÅci.
Podsumowanie
DSIP (Delta Sleep-Inducing Peptide) to unikalny zwiÄ zek badawczy w dziedzinie neurobiologii, endokrynologii i nauk o Ånie. Wersja produkowana przez HPS o czystoÅci ā„99% HPLC zapewnia doskonaÅe wÅaÅciwoÅci badawcze w modelach przedklinicznych.
DziÄki rygorystycznym standardom jakoÅci i peÅnej dokumentacji analitycznej, DSIP od HPS jest idealnym wyborem dla laboratoriĆ³w poszukujÄ cych wiarygodnego ÅŗrĆ³dÅa peptydĆ³w badawczych.
DSIP (Delta Sleep-Inducing Peptide) ā Peptide da Laboratorio ad Alta Purezza (ā„99% HPLC) ā Prodotto da HPS
Panoramica del Prodotto
- Nome del prodotto: DSIP (Delta Sleep-Inducing Peptide)
- Numero CAS: 62568-57-4
- Formula molecolare: Cāā HāāNāāOāā
- Peso molecolare: 848,81 g/mol
- Sequenza: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- Sinonimi: Peptide delta induttore del sonno, peptide DSIP
- Produttore: HPS (High Purity Science)
- Purezza: ā„99% (verificata tramite cromatografia liquida ad alte prestazioni – HPLC)
- Forma: Polvere bianca liofilizzata
- Confezione: Fiala da laboratorio di grado farmaceutico
- Uso previsto: Solo per ricerca scientifica. Non per uso umano o veterinario.
Introduzione al DSIP
Il DSIP (Delta Sleep-Inducing Peptide) ĆØ un neuropeptide di origine naturale scoperto per la prima volta nel 1977 nel cervello dei conigli. Ć stato oggetto di numerosi studi per il suo ruolo nella regolazione del sonno, nei ritmi biologici e nel controllo neuroendocrino. La sua struttura comprende nove amminoacidi, rendendolo un nonapeptide con proprietĆ neuromodulatorie rilevanti.
La versione sintetica di DSIP prodotta da HPS viene realizzata in condizioni di laboratorio altamente controllate, garantendo una purezza ā„99%, confermata da analisi HPLC. Ć formulata specificamente per la ricerca scientifica e assicura risultati affidabili e ripetibili.
Caratteristiche Principali
- Purezza elevata: ā„99% certificata tramite HPLC
- Liofilizzazione di qualitĆ farmaceutica per una conservazione prolungata
- Fornitore affidabile: HPS, leader nei peptidi da laboratorio
- Rigorosi controlli di qualitĆ con tracciabilitĆ del lotto
- Esclusivamente per studi preclinici e ricerca in vitro
Importanza Biologica del DSIP
1. Regolazione del sonno
Il DSIP ĆØ noto per la sua capacitĆ di promuovere il sonno a onde lente (SWS), senza alterare la fase REM. Interviene probabilmente nella modulazione dei neurotrasmettitori come serotonina e noradrenalina.
2. Regolazione ormonale
Influenza la secrezione di diversi ormoni:
- Corticotropina (ACTH)
- Ormone luteinizzante (LH)
- Ormone della crescita (GH)
Ha un ruolo importante nellāasse ipotalamo-ipofisario.
3. Riduzione dello stress
Negli studi animali, il DSIP ha dimostrato di ridurre i livelli di corticosterone, suggerendo un effetto ansiolitico e antistress, probabilmente mediato dal sistema GABAergico e serotoninergico.
4. Percezione del dolore
PuĆ² modulare la soglia del dolore agendo sui recettori oppioidi.
5. Termoregolazione e ritmi circadiani
DSIP sembra influenzare la temperatura corporea e i ritmi biologici, rendendolo un oggetto di studio nella cronobiologia.
Applicazioni nella Ricerca
| Settore di ricerca | Area di studio |
|---|---|
| Neuroscienze | Cicli del sonno, trasmissione sinaptica, dolore |
| Endocrinologia | Regolazione ormonale, ormone della crescita |
| Psicofarmacologia | Ansia, stress, depressione |
| Cronobiologia | Ritmi circadiani, orologio biologico |
| Immunologia | Risposta immunitaria, modulazione delle citochine |
| Metabolismo | Regolazione energetica, metabolismo |
Produzione e Controllo QualitĆ da parte di HPS
HPS (High Purity Science) segue rigorosamente le Buone Pratiche di Fabbricazione (GMP) nella sintesi dei peptidi. Il DSIP ĆØ prodotto con metodo SPPS (Solid-Phase Peptide Synthesis) in ambienti sterili e controllati. Ogni lotto ĆØ purificato e analizzato mediante HPLC per garantire purezza ā„99%.
Parametri di qualitĆ :
- Purezza (HPLC): ā„99%
- Endotossine: <0,1 EU/mg
- Contenuto di umiditĆ : <6%
- SolubilitĆ : Solubile in acqua, acido acetico diluito o DMSO
- Aspetto: Polvere bianca liofilizzata
- Temperatura di conservazione: ā20Ā°C (per conservazione a lungo termine)
Ogni lotto ĆØ accompagnato da un Certificato di Analisi (COA) con numero di lotto, data di scadenza e profilo HPLC.
Analisi HPLC (Sintesi)
Ogni lotto di DSIP viene sottoposto ad analisi HPLC per verificare la catena peptidica, la purezza e lāassenza di contaminazioni.
| Parametro | Valore |
|---|---|
| Tempo di ritenzione | 5,24 minuti |
| Purezza del picco | ā„99,03% |
| ImpuritĆ rilevate | <0,5% |
| Lunghezza dāonda rilevata | 220 nm |
Questi dati assicurano lāaffidabilitĆ sperimentale e la ripetibilitĆ dei risultati.
Istruzioni per la Ricostituzione e la Conservazione
Ricostituzione:
Il DSIP va ricostituito in acqua sterile, soluzione fisiologica allo 0,9% o tampone PBS. La concentrazione deve essere regolata in base al protocollo sperimentale.
Conservazione:
- Forma liofilizzata: stabile a ā20āÆĀ°C per ā„24 mesi
- Dopo ricostituzione: conservare a 2ā8āÆĀ°C e usare entro 7ā14 giorni
- Evitare cicli ripetuti di congelamento e scongelamento
Opzioni di Confezionamento
Disponibile nei seguenti formati:
- Fiala da 1 mg
- Fiala da 2 mg
- Fiala da 5 mg
- Formati personalizzati su richiesta
Le fiale sono sigillate in atmosfera di azoto, protette dalla luce e confezionate sottovuoto per garantire la stabilitĆ del prodotto.
Avvertenze Legali e di Sicurezza
Questo prodotto ĆØ destinato esclusivamente allāuso in laboratorio. Non ĆØ approvato per lāuso diagnostico, terapeutico o per il consumo umano o animale. Lāuso improprio puĆ² comportare responsabilitĆ legali.
Dispositivi di protezione individuale (DPI) obbligatori: guanti, camice da laboratorio, occhiali protettivi. Da utilizzare solo in laboratori certificati sotto supervisione qualificata.
PerchƩ Scegliere i Peptidi HPS?
HPS (High Purity Science) ĆØ unāazienda di fiducia grazie a:
- Certificazioni ISO 9001:2015
- Documentazione completa: COA, HPLC, MS
- Trasparenza nei processi produttivi e supporto tecnico dedicato
- Servizi su misura per lo sviluppo di peptidi personalizzati
HPS ĆØ la scelta preferita da universitĆ , aziende biotech e laboratori farmaceutici per lāaffidabilitĆ e la qualitĆ costante dei suoi peptidi.
Conclusione
DSIP (Delta Sleep-Inducing Peptide) rappresenta un importante strumento di ricerca nei settori della neurobiologia, endocrinologia e scienza del sonno. La sua versione sintetica prodotta da HPS con purezza ā„99% HPLC offre risultati affidabili nei modelli preclinici.
Con il suo impegno nella qualitĆ e nella trasparenza, HPS ĆØ il partner ideale per ricercatori che necessitano di peptidi puri, tracciabili e riproducibili.
DSIP (ŠŠµŠ»ŃŃŠ°-ŃŠ¾Š½-ŠøŠ½Š“ŃŃŠøŃŃŃŃŠøŠ¹ ŠæŠµŠæŃŠøŠ“) ā ŠŠ°Š±Š¾ŃŠ°ŃŠ¾ŃŠ½ŃŠ¹ ŠæŠµŠæŃŠøŠ“ Š²ŃŃŠ¾ŠŗŠ¾Š¹ ŃŠøŃŃŠ¾ŃŃ (ā„99% ŠæŠ¾ HPLC) ā ŠŃŠ¾ŠøŠ·Š²Š¾Š“ŠøŃŠµŠ»Ń: HPS
ŠŠ±ŃŠ°Ń ŠøŠ½ŃŠ¾ŃŠ¼Š°ŃŠøŃ Š¾ ŠæŃŠ¾Š“ŃŠŗŃŠµ
- ŠŠ°Š·Š²Š°Š½ŠøŠµ: DSIP (Delta Sleep-Inducing Peptide)
- CAS-Š½Š¾Š¼ŠµŃ: 62568-57-4
- ŠŠ¾Š»ŠµŠŗŃŠ»ŃŃŠ½Š°Ń ŃŠ¾ŃŠ¼ŃŠ»Š°: Cāā HāāNāāOāā
- ŠŠ¾Š»ŠµŠŗŃŠ»ŃŃŠ½Š°Ń Š¼Š°ŃŃŠ°: 848.81 Š³/Š¼Š¾Š»Ń
- ŠŠ¼ŠøŠ½Š¾ŠŗŠøŃŠ»Š¾ŃŠ½Š°Ń ŠæŠ¾ŃŠ»ŠµŠ“Š¾Š²Š°ŃŠµŠ»ŃŠ½Š¾ŃŃŃ: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- Š”ŠøŠ½Š¾Š½ŠøŠ¼Ń: ŠŠµŠæŃŠøŠ“, ŠøŠ½Š“ŃŃŠøŃŃŃŃŠøŠ¹ Š“ŠµŠ»ŃŃŠ°-ŃŠ¾Š½, DSIP
- ŠŃŠ¾ŠøŠ·Š²Š¾Š“ŠøŃŠµŠ»Ń: HPS (High Purity Science)
- Š§ŠøŃŃŠ¾ŃŠ°: ā„99% (ŠæŠ¾Š“ŃŠ²ŠµŃŠ¶Š“ŠµŠ½Š¾ Š¼ŠµŃŠ¾Š“Š¾Š¼ Š²ŃŃŠ¾ŠŗŠ¾ŃŃŃŠµŠŗŃŠøŠ²Š½Š¾Š¹ Š¶ŠøŠ“ŠŗŠ¾ŃŃŠ½Š¾Š¹ Ń ŃŠ¾Š¼Š°ŃŠ¾Š³ŃŠ°ŃŠøŠø ā HPLC)
- Š¤Š¾ŃŠ¼Š°: ŠŠµŠ»ŃŠ¹ Š»ŠøŠ¾ŃŠøŠ»ŠøŠ·ŠøŃŠ¾Š²Š°Š½Š½ŃŠ¹ ŠæŠ¾ŃŠ¾ŃŠ¾Šŗ
- Š£ŠæŠ°ŠŗŠ¾Š²ŠŗŠ°: Š¤Š»Š°ŠŗŠ¾Š½ ŃŠ°ŃŠ¼Š°ŃŠµŠ²ŃŠøŃŠµŃŠŗŠ¾Š³Š¾ ŠŗŠ»Š°ŃŃŠ° Š“Š»Ń Š»Š°Š±Š¾ŃŠ°ŃŠ¾ŃŠ½ŃŃ ŠøŃŃŠ»ŠµŠ“Š¾Š²Š°Š½ŠøŠ¹
- ŠŠ°Š·Š½Š°ŃŠµŠ½ŠøŠµ: Š¢Š¾Š»ŃŠŗŠ¾ Š“Š»Ń Š»Š°Š±Š¾ŃŠ°ŃŠ¾ŃŠ½Š¾Š³Š¾ ŠøŃŠæŠ¾Š»ŃŠ·Š¾Š²Š°Š½ŠøŃ. ŠŠµ Š“Š»Ń ŠæŃŠøŠ¼ŠµŠ½ŠµŠ½ŠøŃ Ń Š»ŃŠ“ŠµŠ¹ ŠøŠ»Šø Š¶ŠøŠ²Š¾ŃŠ½ŃŃ .
ŠŠ²ŠµŠ“ŠµŠ½ŠøŠµ Š² DSIP
DSIP (Delta Sleep-Inducing Peptide) ā ŃŃŠ¾ ŠæŃŠøŃŠ¾Š“Š½ŃŠ¹ Š½ŠµŠ¹ŃŠ¾ŠæŠµŠæŃŠøŠ“, Š²ŠæŠµŃŠ²ŃŠµ Š²ŃŠ“ŠµŠ»ŠµŠ½Š½ŃŠ¹ ŠøŠ· Š¼Š¾Š·Š³Š° ŠŗŃŠ¾Š»ŠøŠŗŠ¾Š² Š² 1977 Š³Š¾Š“Ń. ŠŠ½ Š°ŠŗŃŠøŠ²Š½Š¾ ŠøŠ·ŃŃŠ°ŠµŃŃŃ Š·Š° ŠµŠ³Š¾ Š²Š»ŠøŃŠ½ŠøŠµ Š½Š° ŃŠµŠ³ŃŠ»ŃŃŠøŃ ŃŠ½Š°, Š±ŠøŠ¾ŃŠøŃŠ¼Ń Šø Š½ŠµŠ¹ŃŠ¾ŃŠ½Š“Š¾ŠŗŃŠøŠ½Š½ŃŠµ ŃŃŠ½ŠŗŃŠøŠø. DSIP ŃŠ¾ŃŃŠ¾ŠøŃ ŠøŠ· Š“ŠµŠ²ŃŃŠø Š°Š¼ŠøŠ½Š¾ŠŗŠøŃŠ»Š¾Ń, ŃŠ²Š»ŃŃŃŃ Š½Š¾Š½Š°ŠæŠµŠæŃŠøŠ“Š¾Š¼ Ń Š²ŃŃŠ°Š¶ŠµŠ½Š½Š¾Š¹ ŃŠµŠ³ŃŠ»ŠøŃŃŃŃŠµŠ¹ Šø Š½ŠµŠ¹ŃŠ¾Š¼Š¾Š“ŃŠ»ŠøŃŃŃŃŠµŠ¹ Š°ŠŗŃŠøŠ²Š½Š¾ŃŃŃŃ.
Š”ŠøŠ½ŃŠµŃŠøŃŠµŃŠŗŠ°Ń ŃŠ¾ŃŠ¼Š° DSIP, ŠæŃŠ¾ŠøŠ·Š²Š¾Š“ŠøŠ¼Š°Ń HPS, ŠøŠ·Š³Š¾ŃŠ°Š²Š»ŠøŠ²Š°ŠµŃŃŃ Š² ŃŃŃŠ¾Š³Š¾ ŠŗŠ¾Š½ŃŃŠ¾Š»ŠøŃŃŠµŠ¼ŃŃ Š»Š°Š±Š¾ŃŠ°ŃŠ¾ŃŠ½ŃŃ ŃŃŠ»Š¾Š²ŠøŃŃ Ń ŃŠøŃŃŠ¾ŃŠ¾Š¹ ā„99%, ŠæŠ¾Š“ŃŠ²ŠµŃŠ¶Š“ŃŠ½Š½Š¾Š¹ HPLC. ŠŃŠµŠæŠ°ŃŠ°Ń ŠæŃŠµŠ“Š½Š°Š·Š½Š°ŃŠµŠ½ ŠøŃŠŗŠ»ŃŃŠøŃŠµŠ»ŃŠ½Š¾ Š“Š»Ń Š½Š°ŃŃŠ½ŃŃ ŠøŃŃŠ»ŠµŠ“Š¾Š²Š°Š½ŠøŠ¹ Šø Š¾Š±ŠµŃŠæŠµŃŠøŠ²Š°ŠµŃ Š²ŃŃŠ¾ŠŗŃŃ Š²Š¾ŃŠæŃŠ¾ŠøŠ·Š²Š¾Š“ŠøŠ¼Š¾ŃŃŃ Šø Š“Š¾ŃŃŠ¾Š²ŠµŃŠ½Š¾ŃŃŃ ŠæŠ¾Š»ŃŃŠ°ŠµŠ¼ŃŃ Š“Š°Š½Š½ŃŃ .
ŠŠ»ŃŃŠµŠ²ŃŠµ Ń Š°ŃŠ°ŠŗŃŠµŃŠøŃŃŠøŠŗŠø
- ŠŃŃŠ¾ŠŗŠ°Ń ŃŠøŃŃŠ¾ŃŠ°: ā„99%, ŠæŠ¾Š“ŃŠ²ŠµŃŠ¶Š“ŠµŠ½Š¾ Š¼ŠµŃŠ¾Š“Š¾Š¼ HPLC
- ŠŠøŠ¾ŃŠøŠ»ŠøŠ·Š°ŃŠøŃ ŃŠ°ŃŠ¼Š°ŃŠµŠ²ŃŠøŃŠµŃŠŗŠ¾Š³Š¾ ŠŗŠ»Š°ŃŃŠ° Š“Š»Ń ŃŃŠ°Š±ŠøŠ»ŃŠ½Š¾Š³Š¾ Ń ŃŠ°Š½ŠµŠ½ŠøŃ
- ŠŠ°Š“ŃŠ¶Š½ŃŠ¹ ŠæŃŠ¾ŠøŠ·Š²Š¾Š“ŠøŃŠµŠ»Ń (HPS) Ń Š°ŠŗŃŠµŠ½ŃŠ¾Š¼ Š½Š° Š»Š°Š±Š¾ŃŠ°ŃŠ¾ŃŠ½ŃŠµ ŠæŠµŠæŃŠøŠ“Ń
- Š”ŃŃŠ¾Š³ŠøŠ¹ ŠŗŠ¾Š½ŃŃŠ¾Š»Ń ŠŗŠ°ŃŠµŃŃŠ²Š° Šø Š¾ŃŃŠ»ŠµŠ¶ŠøŠ²Š°ŠµŠ¼Š¾ŃŃŃ ŠæŠ°ŃŃŠøŠ¹
- ŠŃŠæŠ¾Š»ŃŠ·Š¾Š²Š°Š½ŠøŠµ ŃŠ¾Š»ŃŠŗŠ¾ Š² ŃŠ°Š¼ŠŗŠ°Ń Š“Š¾ŠŗŠ»ŠøŠ½ŠøŃŠµŃŠŗŠøŃ Šø in vitro ŠøŃŃŠ»ŠµŠ“Š¾Š²Š°Š½ŠøŠ¹
ŠŠøŠ¾Š»Š¾Š³ŠøŃŠµŃŠŗŠ¾Šµ Š·Š½Š°ŃŠµŠ½ŠøŠµ DSIP
1. Š ŠµŠ³ŃŠ»ŃŃŠøŃ ŃŠ½Š°
DSIP Š±ŃŠ» Š¾ŃŠŗŃŃŃ Š±Š»Š°Š³Š¾Š“Š°ŃŃ ŃŠ²Š¾ŠµŠ¹ ŃŠæŠ¾ŃŠ¾Š±Š½Š¾ŃŃŠø Š²ŃŠ·ŃŠ²Š°ŃŃ Š“ŠµŠ»ŃŃŠ°-ŃŠ¾Š½ (Š¼ŠµŠ“Š»ŠµŠ½Š½ŃŠµ Š²Š¾Š»Š½Ń ŃŠ½Š° ā SWS), Š½Šµ Š½Š°ŃŃŃŠ°Ń ŃŠ°Š·Ń Š±ŃŃŃŃŠ¾Š³Š¾ ŃŠ½Š° (REM). ŠŠµŠæŃŠøŠ“ Š¼Š¾Š¶ŠµŃ Š¼Š¾Š“ŃŠ»ŠøŃŠ¾Š²Š°ŃŃ Š°ŠŗŃŠøŠ²Š½Š¾ŃŃŃ Š½ŠµŠ¹ŃŠ¾Š¼ŠµŠ“ŠøŠ°ŃŠ¾ŃŠ¾Š², ŃŠ°ŠŗŠøŃ
ŠŗŠ°Šŗ ŃŠµŃŠ¾ŃŠ¾Š½ŠøŠ½ Šø Š½Š¾ŃŠ°Š“ŃŠµŠ½Š°Š»ŠøŠ½.
2. ŠŠ½Š“Š¾ŠŗŃŠøŠ½Š½Š°Ń ŃŠµŠ³ŃŠ»ŃŃŠøŃ
DSIP Š²Š»ŠøŃŠµŃ Š½Š° ŃŠµŠŗŃŠµŃŠøŃ ŃŠ»ŠµŠ“ŃŃŃŠøŃ
Š³Š¾ŃŠ¼Š¾Š½Š¾Š²:
- ŠŠŠ¢Š (Š°Š“ŃŠµŠ½Š¾ŠŗŠ¾ŃŃŠøŠŗŠ¾ŃŃŠ¾ŠæŠ½ŃŠ¹ Š³Š¾ŃŠ¼Š¾Š½)
- ŠŠ (Š»ŃŃŠµŠøŠ½ŠøŠ·ŠøŃŃŃŃŠøŠ¹ Š³Š¾ŃŠ¼Š¾Š½)
- Š”Š¾Š¼Š°ŃŠ¾ŃŃŠ¾ŠæŠøŠ½ (Š³Š¾ŃŠ¼Š¾Š½ ŃŠ¾ŃŃŠ°)
Š¢Š°ŠŗŠ¶Šµ ŃŃŠ°ŃŃŠ²ŃŠµŃ Š² ŃŠµŠ³ŃŠ»ŃŃŠøŠø Š³ŠøŠæŠ¾ŃŠ°Š»Š°Š¼Š¾-Š³ŠøŠæŠ¾ŃŠøŠ·Š°ŃŠ½Š¾Š¹ Š¾ŃŠø.
3. ŠŠ¾Š“ŃŠ»ŃŃŠøŃ ŃŃŃŠµŃŃŠ°
Š ŃŠŗŃŠæŠµŃŠøŠ¼ŠµŠ½ŃŠ°Ń
Š½Š° Š¶ŠøŠ²Š¾ŃŠ½ŃŃ
DSIP ŃŠ½ŠøŠ¶Š°Š» ŃŃŠ¾Š²ŠµŠ½Ń ŠŗŠ¾ŃŃŠøŠŗŠ¾ŃŃŠµŃŠ¾Š½Š°, ŃŃŠ¾ ŃŠŗŠ°Š·ŃŠ²Š°ŠµŃ Š½Š° ŠµŠ³Š¾ Š°Š½ŠŗŃŠøŠ¾Š»ŠøŃŠøŃŠµŃŠŗŠ¾Šµ Šø Š°Š½ŃŠøŃŃŃŠµŃŃŠ¾Š²Š¾Šµ Š“ŠµŠ¹ŃŃŠ²ŠøŠµ. ŠŃŃŠµŠŗŃ, ŠæŃŠµŠ“ŠæŠ¾Š»Š¾Š¶ŠøŃŠµŠ»ŃŠ½Š¾, ŃŠ²ŃŠ·Š°Š½ Ń GABA- Šø ŃŠµŃŠ¾ŃŠ¾Š½ŠøŠ½ŠµŃŠ³ŠøŃŠµŃŠŗŠ¾Š¹ ŃŠøŃŃŠµŠ¼Š¾Š¹.
4. ŠŠ»ŠøŃŠ½ŠøŠµ Š½Š° Š²Š¾ŃŠæŃŠøŃŃŠøŠµ Š±Š¾Š»Šø
DSIP Š¼Š¾Š¶ŠµŃ Š²Š¾Š·Š“ŠµŠ¹ŃŃŠ²Š¾Š²Š°ŃŃ Š½Š° Š¾ŠæŠøŠ¾ŠøŠ“Š½ŃŠµ ŃŠµŃŠµŠæŃŠ¾ŃŃ Šø ŠøŠ·Š¼ŠµŠ½ŃŃŃ Š±Š¾Š»ŠµŠ²Š¾Š¹ ŠæŠ¾ŃŠ¾Š³.
5. Š¢ŠµŃŠ¼Š¾ŃŠµŠ³ŃŠ»ŃŃŠøŃ Šø ŃŠøŃŠŗŠ°Š“Š½ŃŠµ ŃŠøŃŠ¼Ń
DSIP ŃŃŠ°ŃŃŠ²ŃŠµŃ Š² ŃŠµŠ³ŃŠ»ŃŃŠøŠø ŃŠµŠ¼ŠæŠµŃŠ°ŃŃŃŃ ŃŠµŠ»Š° Šø Š±ŠøŠ¾Š»Š¾Š³ŠøŃŠµŃŠŗŠøŃ
ŃŠøŃŠ¼Š¾Š², ŃŃŠ¾ Š“ŠµŠ»Š°ŠµŃ ŠµŠ³Š¾ Š¾Š±ŃŠµŠŗŃŠ¾Š¼ ŠøŠ½ŃŠµŃŠµŃŠ° Š² Ń
ŃŠ¾Š½Š¾Š±ŠøŠ¾Š»Š¾Š³ŠøŠø Šø Ń
ŃŠ¾Š½Š¾Š¼ŠµŠ“ŠøŃŠøŠ½Šµ.
ŠŠ±Š»Š°ŃŃŠø ŠæŃŠøŠ¼ŠµŠ½ŠµŠ½ŠøŃ Š² ŠøŃŃŠ»ŠµŠ“Š¾Š²Š°Š½ŠøŃŃ
| ŠŠ°ŃŃŠ½Š°Ń Š¾Š±Š»Š°ŃŃŃ | ŠŠ±ŃŠµŠŗŃŃ ŠøŠ·ŃŃŠµŠ½ŠøŃ |
|---|---|
| ŠŠµŠ¹ŃŠ¾Š±ŠøŠ¾Š»Š¾Š³ŠøŃ | Š¦ŠøŠŗŠ»Ń ŃŠ½Š°, Š½ŠµŠ¹ŃŠ¾ŃŃŠ°Š½ŃŠ¼ŠøŃŃŠµŃŃ, Š²Š¾ŃŠæŃŠøŃŃŠøŠµ Š±Š¾Š»Šø |
| ŠŠ½Š“Š¾ŠŗŃŠøŠ½Š¾Š»Š¾Š³ŠøŃ | ŠŠ¾ŃŠ¼Š¾Š½Š°Š»ŃŠ½ŃŠ¹ Š±Š°Š»Š°Š½Ń, Š³Š¾ŃŠ¼Š¾Š½ ŃŠ¾ŃŃŠ° |
| ŠŃŠøŃ Š¾ŃŠ°ŃŠ¼Š°ŠŗŠ¾Š»Š¾Š³ŠøŃ | Š”ŃŃŠµŃŃ, ŃŃŠµŠ²Š¾Š¶Š½Š¾ŃŃŃ, Š“ŠµŠæŃŠµŃŃŠøŃ |
| Š„ŃŠ¾Š½Š¾Š±ŠøŠ¾Š»Š¾Š³ŠøŃ | Š¦ŠøŃŠŗŠ°Š“Š½ŃŠµ ŃŠøŃŠ¼Ń, Š±ŠøŠ¾Š»Š¾Š³ŠøŃŠµŃŠŗŠøŠµ ŃŠ°ŃŃ |
| ŠŠ¼Š¼ŃŠ½Š¾Š»Š¾Š³ŠøŃ | Š¦ŠøŃŠ¾ŠŗŠøŠ½Ń, ŠøŠ¼Š¼ŃŠ½Š½ŃŠ¹ Š¾ŃŠ²ŠµŃ |
| ŠŠµŃŠ°Š±Š¾Š»ŠøŠ·Š¼ | ŠŠ½ŠµŃŠ³ŠµŃŠøŃŠµŃŠŗŠøŠ¹ Š¾Š±Š¼ŠµŠ½, ŃŠŗŠ¾ŃŠ¾ŃŃŃ Š¼ŠµŃŠ°Š±Š¾Š»ŠøŠ·Š¼Š° |
ŠŃŠ¾ŠøŠ·Š²Š¾Š“ŃŃŠ²Š¾ Šø ŠŗŠ¾Š½ŃŃŠ¾Š»Ń ŠŗŠ°ŃŠµŃŃŠ²Š° Š¾Ń HPS
HPS (High Purity Science) ŠæŃŠøŠ¼ŠµŠ½ŃŠµŃ ŃŃŃŠ¾Š³ŠøŠµ ŃŃŠ°Š½Š“Š°ŃŃŃ GMP ŠæŃŠø ŃŠøŠ½ŃŠµŠ·Šµ ŠæŠµŠæŃŠøŠ“Š¾Š². DSIP ŠæŃŠ¾ŠøŠ·Š²Š¾Š“ŠøŃŃŃ Š¼ŠµŃŠ¾Š“Š¾Š¼ ŃŠ²ŃŃŠ“Š¾ŃŠ°Š·Š½Š¾Š³Š¾ ŠæŠµŠæŃŠøŠ“Š½Š¾Š³Š¾ ŃŠøŠ½ŃŠµŠ·Š° (SPPS) Š² ŃŃŠµŃŠøŠ»ŃŠ½ŃŃ ŃŃŠ»Š¾Š²ŠøŃŃ ŠæŃŠø ŠŗŠ¾Š½ŃŃŠ¾Š»ŠøŃŃŠµŠ¼Š¾Š¹ ŃŠµŠ¼ŠæŠµŃŠ°ŃŃŃŠµ. ŠŠ°Š¶Š“Š°Ń ŠæŠ°ŃŃŠøŃ ŠæŃŠ¾Ń Š¾Š“ŠøŃ Š¾ŃŠøŃŃŠŗŃ Šø ŠæŃŠ¾Š²ŠµŃŠŗŃ Ń ŠæŠ¾Š¼Š¾ŃŃŃ HPLC, Š¾Š±ŠµŃŠæŠµŃŠøŠ²Š°Ń ŃŠøŃŃŠ¾ŃŃ ā„99%.
ŠŠ°ŃŠµŃŃŠ²ŠµŠ½Š½ŃŠµ ŠæŠ°ŃŠ°Š¼ŠµŃŃŃ:
- Š§ŠøŃŃŠ¾ŃŠ° (HPLC): ā„99%
- Š£ŃŠ¾Š²ŠµŠ½Ń ŃŠ½Š“Š¾ŃŠ¾ŠŗŃŠøŠ½Š¾Š²: <0.1 EU/mg
- ŠŠ»Š°Š¶Š½Š¾ŃŃŃ: <6%
- Š Š°ŃŃŠ²Š¾ŃŠøŠ¼Š¾ŃŃŃ: Š Š°ŃŃŠ²Š¾ŃŠøŠ¼ Š² Š²Š¾Š“Šµ, ŃŠ°Š·Š±Š°Š²Š»ŠµŠ½Š½Š¾Š¹ ŃŠŗŃŃŃŠ½Š¾Š¹ ŠŗŠøŃŠ»Š¾ŃŠµ ŠøŠ»Šø DMSO
- ŠŠ½ŠµŃŠ½ŠøŠ¹ Š²ŠøŠ“: ŠŠµŠ»ŃŠ¹ Š»ŠøŠ¾ŃŠøŠ»ŠøŠ·ŠøŃŠ¾Š²Š°Š½Š½ŃŠ¹ ŠæŠ¾ŃŠ¾ŃŠ¾Šŗ
- Š„ŃŠ°Š½ŠµŠ½ŠøŠµ: ā20āÆĀ°C (Š“Š»Ń Š“Š»ŠøŃŠµŠ»ŃŠ½Š¾Š³Š¾ Ń ŃŠ°Š½ŠµŠ½ŠøŃ)
ŠŠ°Š¶Š“Š°Ń ŠæŠ°ŃŃŠøŃ ŃŠ¾ŠæŃŠ¾Š²Š¾Š¶Š“Š°ŠµŃŃŃ ŃŠµŃŃŠøŃŠøŠŗŠ°ŃŠ¾Š¼ Š°Š½Š°Š»ŠøŠ·Š° (COA) Ń Š½Š¾Š¼ŠµŃŠ¾Š¼ ŠæŠ°ŃŃŠøŠø, ŃŃŠ¾ŠŗŠ¾Š¼ Š³Š¾Š“Š½Š¾ŃŃŠø Šø HPLC-ŠæŃŠ¾ŃŠøŠ»ŠµŠ¼.
HPLC-Š°Š½Š°Š»ŠøŠ· (ŃŠ²Š¾Š“ŠŗŠ°)
ŠŠ°Š¶Š“Š°Ń ŠæŠ°ŃŃŠøŃ DSIP ŠæŃŠ¾Ń Š¾Š“ŠøŃ Š°Š½Š°Š»ŠøŠ· HPLC, ŠæŠ¾Š“ŃŠ²ŠµŃŠ¶Š“Š°ŃŃŠøŠ¹ ŃŃŃŃŠŗŃŃŃŃ ŠæŠµŠæŃŠøŠ“Š°, ŃŠøŃŃŠ¾ŃŃ Šø Š¾ŃŃŃŃŃŃŠ²ŠøŠµ Š·Š°Š³ŃŃŠ·Š½ŠµŠ½ŠøŠ¹.
| ŠŠ°ŃŠ°Š¼ŠµŃŃ | ŠŠ½Š°ŃŠµŠ½ŠøŠµ |
|---|---|
| ŠŃŠµŠ¼Ń ŃŠ“ŠµŃŠ¶ŠøŠ²Š°Š½ŠøŃ | 5,24 Š¼ŠøŠ½ŃŃŃ |
| Š§ŠøŃŃŠ¾ŃŠ° Š¾ŃŠ½Š¾Š²Š½Š¾Š³Š¾ ŠæŠøŠŗŠ° | ā„99,03% |
| ŠŠ±Š½Š°ŃŃŠ¶ŠµŠ½Š½ŃŠµ ŠæŃŠøŠ¼ŠµŃŠø | <0,5% |
| ŠŠ»ŠøŠ½Š° Š²Š¾Š»Š½Ń ŃŠµŠ³ŠøŃŃŃŠ°ŃŠøŠø | 220 Š½Š¼ |
ŠŠ½Š°Š»ŠøŠ· Š³Š°ŃŠ°Š½ŃŠøŃŃŠµŃ Š½Š°Š“ŃŠ¶Š½Š¾ŃŃŃ Šø Š²Š¾ŃŠæŃŠ¾ŠøŠ·Š²Š¾Š“ŠøŠ¼Š¾ŃŃŃ ŃŠµŠ·ŃŠ»ŃŃŠ°ŃŠ¾Š².
Š ŠµŠŗŠ¾Š¼ŠµŠ½Š“Š°ŃŠøŠø ŠæŠ¾ ŃŠ°ŃŃŠ²Š¾ŃŠµŠ½ŠøŃ Šø Ń ŃŠ°Š½ŠµŠ½ŠøŃ
Š Š°ŃŃŠ²Š¾ŃŠµŠ½ŠøŠµ:
DSIP ŃŠ»ŠµŠ“ŃŠµŃ ŃŠ°ŃŃŠ²Š¾ŃŃŃŃ Š² ŃŃŠµŃŠøŠ»ŃŠ½Š¾Š¹ Š“ŠøŃŃŠøŠ»Š»ŠøŃŠ¾Š²Š°Š½Š½Š¾Š¹ Š²Š¾Š“Šµ, ŃŠøŠ·ŠøŠ¾Š»Š¾Š³ŠøŃŠµŃŠŗŠ¾Š¼ ŃŠ°ŃŃŠ²Š¾ŃŠµ (0,9% NaCl) ŠøŠ»Šø Š±ŃŃŠµŃŠ½Š¾Š¼ ŃŠ°ŃŃŠ²Š¾ŃŠµ (Š½Š°ŠæŃŠøŠ¼ŠµŃ, PBS). ŠŠ¾Š½ŃŠµŠ½ŃŃŠ°ŃŠøŃ ŠæŠ¾Š“Š±ŠøŃŠ°ŠµŃŃŃ Š² Š·Š°Š²ŠøŃŠøŠ¼Š¾ŃŃŠø Š¾Ń ŠæŃŠ¾ŃŠ¾ŠŗŠ¾Š»Š° ŠøŃŃŠ»ŠµŠ“Š¾Š²Š°Š½ŠøŃ.
Š„ŃŠ°Š½ŠµŠ½ŠøŠµ:
- ŠŠøŠ¾ŃŠøŠ»ŠøŠ·ŠøŃŠ¾Š²Š°Š½Š½Š°Ń ŃŠ¾ŃŠ¼Š°: ŃŃŠ°Š±ŠøŠ»ŃŠ½Š° ŠæŃŠø ā20āÆĀ°C Š½Šµ Š¼ŠµŠ½ŠµŠµ 24 Š¼ŠµŃŃŃŠµŠ²
- ŠŠ¾ŃŠ»Šµ ŃŠ°ŃŃŠ²Š¾ŃŠµŠ½ŠøŃ: Ń ŃŠ°Š½ŠøŃŃ ŠæŃŠø 2ā8āÆĀ°C, ŠøŃŠæŠ¾Š»ŃŠ·Š¾Š²Š°ŃŃ Š² ŃŠµŃŠµŠ½ŠøŠµ 7ā14 Š“Š½ŠµŠ¹
- ŠŠ·Š±ŠµŠ³Š°ŃŃ ŠæŠ¾Š²ŃŠ¾ŃŠ½ŃŃ ŃŠøŠŗŠ»Š¾Š² Š·Š°Š¼Š¾ŃŠ°Š¶ŠøŠ²Š°Š½ŠøŃ Šø ŃŠ°Š·Š¼Š¾ŃŠ°Š¶ŠøŠ²Š°Š½ŠøŃ
ŠŠ°ŃŠøŠ°Š½ŃŃ ŃŠæŠ°ŠŗŠ¾Š²ŠŗŠø
ŠŠ¾ŃŃŃŠæŠµŠ½ Š² ŃŠ»Š°ŠŗŠ¾Š½Š°Ń :
- 1 Š¼Š³
- 2 Š¼Š³
- 5 Š¼Š³
- ŠŠ½Š“ŠøŠ²ŠøŠ“ŃŠ°Š»ŃŠ½ŃŠµ Š¾ŠæŃŠ¾Š²ŃŠµ Š·Š°ŠŗŠ°Š·Ń ā ŠæŠ¾ Š·Š°ŠæŃŠ¾ŃŃ
Š¤Š»Š°ŠŗŠ¾Š½Ń Š·Š°ŠæŠµŃŠ°ŃŠ°Š½Ń Š² ŠøŠ½ŠµŃŃŠ½Š¾Š¹ ŃŃŠµŠ“Šµ (Š°Š·Š¾Ń), Š·Š°ŃŠøŃŠµŠ½Ń Š¾Ń ŃŠ²ŠµŃŠ° Šø ŃŠæŠ°ŠŗŠ¾Š²Š°Š½Ń Š²Š°ŠŗŃŃŠ¼Š½Š¾ Š“Š»Ń Š¼Š°ŠŗŃŠøŠ¼Š°Š»ŃŠ½Š¾Š¹ ŃŃŠ°Š±ŠøŠ»ŃŠ½Š¾ŃŃŠø.
Š®ŃŠøŠ“ŠøŃŠµŃŠŗŠ°Ń ŠøŠ½ŃŠ¾ŃŠ¼Š°ŃŠøŃ Šø Š¼ŠµŃŃ Š±ŠµŠ·Š¾ŠæŠ°ŃŠ½Š¾ŃŃŠø
ŠŃŠ¾Š“ŃŠŗŃ ŠæŃŠµŠ“Š½Š°Š·Š½Š°ŃŠµŠ½ ŠøŃŠŗŠ»ŃŃŠøŃŠµŠ»ŃŠ½Š¾ Š“Š»Ń Š½Š°ŃŃŠ½ŃŃ ŠøŃŃŠ»ŠµŠ“Š¾Š²Š°Š½ŠøŠ¹. ŠŠµ ŠæŃŠµŠ“Š½Š°Š·Š½Š°ŃŠµŠ½ Š“Š»Ń Š“ŠøŠ°Š³Š½Š¾ŃŃŠøŠŗŠø, Š»ŠµŃŠµŠ½ŠøŃ ŠøŠ»Šø ŠæŃŠøŠ¼ŠµŠ½ŠµŠ½ŠøŃ Ń ŃŠµŠ»Š¾Š²ŠµŠŗŠ°/Š¶ŠøŠ²Š¾ŃŠ½ŃŃ . ŠŠµŠæŃŠ°Š²Š¾Š¼ŠµŃŠ½Š¾Šµ ŠøŃŠæŠ¾Š»ŃŠ·Š¾Š²Š°Š½ŠøŠµ Š¼Š¾Š¶ŠµŃ ŠæŠ¾Š²Š»ŠµŃŃ ŃŃŠøŠ“ŠøŃŠµŃŠŗŃŃ Š¾ŃŠ²ŠµŃŃŃŠ²ŠµŠ½Š½Š¾ŃŃŃ.
Š”ŃŠµŠ“ŃŃŠ²Š° ŠøŠ½Š“ŠøŠ²ŠøŠ“ŃŠ°Š»ŃŠ½Š¾Š¹ Š·Š°ŃŠøŃŃ (Š”ŠŠ) Š¾Š±ŃŠ·Š°ŃŠµŠ»ŃŠ½Ń: ŠæŠµŃŃŠ°ŃŠŗŠø, Š»Š°Š±Š¾ŃŠ°ŃŠ¾ŃŠ½ŃŠ¹ Ń Š°Š»Š°Ń, Š·Š°ŃŠøŃŠ½ŃŠµ Š¾ŃŠŗŠø. ŠŃŠæŠ¾Š»ŃŠ·Š¾Š²Š°ŃŃ ŃŠ¾Š»ŃŠŗŠ¾ Š² ŃŠµŃŃŠøŃŠøŃŠøŃŠ¾Š²Š°Š½Š½Š¾Š¹ Š»Š°Š±Š¾ŃŠ°ŃŠ¾ŃŠøŠø ŠæŠ¾Š“ ŠŗŠ¾Š½ŃŃŠ¾Š»ŠµŠ¼ ŠŗŠ²Š°Š»ŠøŃŠøŃŠøŃŠ¾Š²Š°Š½Š½Š¾Š³Š¾ ŠæŠµŃŃŠ¾Š½Š°Š»Š°.
ŠŠ¾ŃŠµŠ¼Ń Š²ŃŠ±ŠøŃŠ°ŃŃ HPS?
ŠŠ¾Š¼ŠæŠ°Š½ŠøŃ HPS (High Purity Science) ā ŠæŃŠøŠ·Š½Š°Š½Š½ŃŠ¹ ŠæŃŠ¾ŠøŠ·Š²Š¾Š“ŠøŃŠµŠ»Ń Š»Š°Š±Š¾ŃŠ°ŃŠ¾ŃŠ½ŃŃ ŠæŠµŠæŃŠøŠ“Š¾Š² Š±Š»Š°Š³Š¾Š“Š°ŃŃ:
- Š”ŠµŃŃŠøŃŠøŠŗŠ°ŃŠøŠø ISO 9001:2015
- ŠŠ¾Š»Š½Š¾Š¹ Š°Š½Š°Š»ŠøŃŠøŃŠµŃŠŗŠ¾Š¹ Š“Š¾ŠŗŃŠ¼ŠµŠ½ŃŠ°ŃŠøŠø (COA, HPLC, Š¼Š°ŃŃ-ŃŠæŠµŠŗŃŃŠ¾Š¼ŠµŃŃŠøŃ)
- ŠŃŠ¾Š·ŃŠ°ŃŠ½Š¾ŃŃŠø ŠæŠ¾ŃŃŠ°Š²Š¾Šŗ Šø ŃŠµŃ Š½ŠøŃŠµŃŠŗŠ¾Š¹ ŠæŠ¾Š“Š“ŠµŃŠ¶ŠŗŠµ
- Š£ŃŠ»ŃŠ³Š°Š¼ ŠæŠ¾ ŠøŠ½Š“ŠøŠ²ŠøŠ“ŃŠ°Š»ŃŠ½Š¾Š¼Ń ŃŠøŠ½ŃŠµŠ·Ń ŠæŠµŠæŃŠøŠ“Š¾Š²
ŠŃŃŠ»ŠµŠ“Š¾Š²Š°ŃŠµŠ»ŃŃŠŗŠøŠµ ŠøŠ½ŃŃŠøŃŃŃŃ, ŃŠ°ŃŠ¼Š°ŃŠµŠ²ŃŠøŃŠµŃŠŗŠøŠµ Šø Š±ŠøŠ¾ŃŠµŃ Š½Š¾Š»Š¾Š³ŠøŃŠµŃŠŗŠøŠµ ŠŗŠ¾Š¼ŠæŠ°Š½ŠøŠø ŠæŠ¾ Š²ŃŠµŠ¼Ń Š¼ŠøŃŃ Š“Š¾Š²ŠµŃŃŃŃ HPS Š·Š° Š½Š°Š“ŃŠ¶Š½Š¾ŃŃŃ, ŠŗŠ°ŃŠµŃŃŠ²Š¾ Šø Š“Š¾ŃŃŃŠæŠ½ŃŠµ ŃŠµŠ½Ń.
ŠŠ°ŠŗŠ»ŃŃŠµŠ½ŠøŠµ
DSIP (Delta Sleep-Inducing Peptide) ā ŠæŠµŃŃŠæŠµŠŗŃŠøŠ²Š½ŃŠ¹ ŠæŠµŠæŃŠøŠ“ Š² Š¾Š±Š»Š°ŃŃŠø Š½ŠµŠ¹ŃŠ¾Š±ŠøŠ¾Š»Š¾Š³ŠøŠø, ŃŠ½Š“Š¾ŠŗŃŠøŠ½Š¾Š»Š¾Š³ŠøŠø Šø ŠøŃŃŠ»ŠµŠ“Š¾Š²Š°Š½ŠøŠ¹ ŃŠ½Š°. ŠŃŠ¾ŠøŠ·Š²Š¾Š“ŠøŠ¼ŃŠ¹ ŠŗŠ¾Š¼ŠæŠ°Š½ŠøŠµŠ¹ HPS Ń ŃŠøŃŃŠ¾ŃŠ¾Š¹ ā„99% ŠæŠ¾ HPLC, Š¾Š½ Š¾Š±ŠµŃŠæŠµŃŠøŠ²Š°ŠµŃ Š²ŃŃŠ¾ŠŗŃŃ ŃŠ¾ŃŠ½Š¾ŃŃŃ Šø Š²Š¾ŃŠæŃŠ¾ŠøŠ·Š²Š¾Š“ŠøŠ¼Š¾ŃŃŃ Š² Š“Š¾ŠŗŠ»ŠøŠ½ŠøŃŠµŃŠŗŠøŃ ŠøŃŃŠ»ŠµŠ“Š¾Š²Š°Š½ŠøŃŃ .
ŠŠ»Š°Š³Š¾Š“Š°ŃŃ ŃŃŃŠ¾Š³ŠøŠ¼ ŃŃŠ°Š½Š“Š°ŃŃŠ°Š¼ ŠŗŠ°ŃŠµŃŃŠ²Š°, HPS ŠæŃŠµŠ“Š»Š°Š³Š°ŠµŃ DSIP, ŠŗŠ¾ŃŠ¾ŃŠ¾Š¼Ń Š¼Š¾Š¶Š½Š¾ Š“Š¾Š²ŠµŃŃŃŃ ā Ń ŠæŠ¾Š»Š½Š¾Š¹ Š“Š¾ŠŗŃŠ¼ŠµŠ½ŃŠ°ŃŠøŠµŠ¹ Šø Š»Š°Š±Š¾ŃŠ°ŃŠ¾ŃŠ½Š¾Š¹ ŃŠæŠ°ŠŗŠ¾Š²ŠŗŠ¾Š¹.
DSIP (ėøķ ģė©“ ģ ė ķ©ķģ“ė) ā ź³ ģė ģ¤ķģ¤ ģ ģ© ķ©ķģ“ė (ā„99% HPLC) ā ģ ģ”°ģ¬: HPS
š¦ ģ ķ ź°ģ
- ģ ķėŖ : DSIP (Delta Sleep-Inducing Peptide)
- CAS ė²ķø: 62568-57-4
- ė¶ģģ: Cāā HāāNāāOāā
- ė¶ģė: 848.81 g/mol
- ģėÆøė øģ° ģģ“: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- ėģģ“: ėøķ ģė©“ ģ ė ķ©ķģ“ė, DSIP ķ©ķģ“ė
- ģ ģ”°ģ¬: HPS (High Purity Science)
- ģė: ā„99% (ź³ ģ±ė„ ģ”ģ²“ ķ¬ė”ė§ķ ź·øėķ¼ HPLCė” ź²ģ¦ėØ)
- ķķ: ė°±ģ ėź²° ź±“ģ”° ė¶ė§
- ķ¬ģ„: ģ ģ½ ė±źø ģ¤ķģ© ė°ģ“ģ
- ģ¬ģ© ėŖ©ģ : ģ°źµ¬ ģ ģ© (ģøģ²“ ėė ėė¬¼ģ ģ¬ģ© źøģ§)
š§¬ DSIP ģź°
**DSIP (Delta Sleep-Inducing Peptide)**ė 1977ė ķ ė¼ģ ėģģ ģ²ģ ė¶ė¦¬ė ģģ° ė°ģģ± ģ ź²½ ķ©ķģ“ėģ ėė¤. ģ“ ķ©ķģ“ėė ģė©“ ģ”°ģ , ģģ²“ ė¦¬ė¬ ė° ģ ź²½ė“ė¶ė¹ ģ”°ģ ź³¼ ź“ė Øė ģ°źµ¬ģģ ź“ė²ģķź² ģ¬ģ©ėź³ ģģµėė¤. 9ź°ģ ģėÆøė øģ°ģ¼ė” źµ¬ģ±ė ė øėķ©ķģ“ėė”, ė¤ģķ ģė¦¬ķģ ģ”°ģ źø°ė„ģ ź°ģ§ź³ ģģµėė¤.
HPSģģ ģ ģ”°ķ ģ“ ķ©ģ± DSIPė ģź²©ķ ģ¤ķģ¤ ķź²½ģģ ģ ģ”°ėė©°, HPLC ė¶ģģ ķµķ“ ā„99% ģėė„¼ ė³“ģ„ķ©ėė¤. ģ ė¢°ė ėģ ģė¦¬ķģ ė° ģ ź²½ź³¼ķ ģ°źµ¬ė„¼ ģķ ģ“ģģ ģø ģ¤ķģ© ģģ½ģ ėė¤.
ā ģ£¼ģ ķ¹ģ§
- ź³ ģė ā„99%, HPLCė” ź²ģ¦
- ģ ģ½ ė±źø ėź²° ź±“ģ”°ė” ģ„źø° ģģ ģ± ķė³“
- HPS ģ ģ”° ā ģ°źµ¬ģ© ķ©ķģ“ė ė¶ģ¼ģ ģ ė¢°ģ± ģė ėøėė
- ģź²©ķ ķģ§ ź“ė¦¬ ė° ģģ° ģ“ė „ ģ¶ģ ź°ė„
- ģ¤ģ§ ģ¤ķģ¤ ģ ģ© (ģ ģģ ė° in vitro ģ°źµ¬ģė§ ģ¬ģ©)
š§ DSIPģ ģė¬¼ķģ ģ¤ģģ±
1. ģė©“ ģ”°ģ
DSIPė ģķģė©“(SWS)ģ ģ“ģ§ķė ķØź³¼ė” ģ²ģ ģ£¼ėŖ©ė°ģģµėė¤. REM ģė©“ģė ģķ„ģ ģ£¼ģ§ ģģ¼ė©°, ģøė”ķ ė ė° ė
øė„“ģķ¼ė¤ķė¦° ė± ģė©“ ź“ė Ø ģ ź²½ģ ė¬ė¬¼ģ§ģ ė°©ģ¶ģ ģ”°ģ ķ ģ ģģµėė¤.
2. ė“ė¶ė¹ ģ”°ģ
DSIPė ė¤ģź³¼ ź°ģ ķøė„“ėŖ¬ģ ė¶ė¹ģ ģķ„ģ ėÆøģ¹ ģ ģģµėė¤:
- ė¶ģ ķ¼ģ§ģź·¹ķøė„“ėŖ¬ (ACTH)
- ķ©ģ²“ķģ±ķøė„“ėŖ¬ (LH)
- ģ±ģ„ķøė„“ėŖ¬ (GH)
ģ“ė ģģķė¶-ėķģģ²“ ģ¶ģ ģ”°ģ ź³¼ ź“ė Øģ“ ģģµėė¤.
3. ģ¤ķøė ģ¤ ģķ
DSIPė ėė¬¼ ģ¤ķģģ ģ½ė„“ķ°ģ½ģ¤ķ
ė” ģģ¹ė„¼ ė®ģ¶ė ķØź³¼ė„¼ ė³“ģ¬ģ£¼ė©°, ė¶ģ ģķ ė° ķģ¤ķøė ģ¤ ģģ©ź³¼ ģ°ź“ģ“ ģģµėė¤. ģ“ė GABA ė° ģøė”ķ ė ģģ¤ķ
ź³¼ ź“ė Øėģ“ ģģ ģ ģģµėė¤.
4. ķµģ¦ ģøģ§
DSIPė ģ¤ķ¼ģ¤ģ“ė ģģ©ģ²“ ģģ¤ķ
ģ ģ”°ģ ķģ¬ ķµģ¦ ėƼź°ėė„¼ ė³ķģķ¬ ģ ģģµėė¤.
5. ģ²“ģØ ģ”°ģ ė° ģģ²“ė¦¬ė¬
DSIPė ģ²“ģØ ģ”°ģ ė° ģģ²“ ģź³ źø°ė„ģ ź“ģ¬ķė©°, ķ¬ė”ė
øė°ģ“ģ¬ė”ģ§ ė° ģź° ģķ(Chronotherapy) ė¶ģ¼ģģ ģ°źµ¬ėź³ ģģµėė¤.
š¬ ģ°źµ¬ ģģ© ė¶ģ¼
| ģ°źµ¬ ė¶ģ¼ | ģ£¼ģ ģģ© |
|---|---|
| ģ ź²½ź³¼ķ | ģė©“ ģ£¼źø°, ģ ź²½ģ ė¬, ķµģ¦ ģ”°ģ |
| ė“ė¶ė¹ķ | ķøė„“ėŖ¬ ź· ķ, ģ±ģ„ķøė„“ėŖ¬ ź“ė Ø ģ°źµ¬ |
| ģ ģ ģ½ė¦¬ķ | ģ¤ķøė ģ¤, ė¶ģ, ģ°ģøģ¦ ėŖØėø |
| ķ¬ė”ė øė°ģ“ģ¬ė”ģ§ | ģģ²“ ģź³, ģ¼ģ£¼źø° ė¦¬ė¬ ģ°źµ¬ |
| ė©“ģķ | ė©“ģ ė°ģ, ģ¬ģ“ķ ģ¹“ģø ģ”°ģ |
| ėģ¬ ģ°źµ¬ | ģėģ§ ź· ķ, ėģ¬ģØ ģ”°ģ |
š HPSģ ģ ģ”° ė° ķģ§ ź“ė¦¬
**HPS (High Purity Science)**ė ź³ ģė ķ©ķģ“ė ķ©ģ±ģ ģķ“ **GMP(ģ°ģģ ģ”°ź“ė¦¬źø°ģ¤)**ģ ģ¤ģķ©ėė¤. DSIPė ź³ ģ²“ģ ķ©ķģ“ė ķ©ģ±(SPPS) ė°©ģģ¼ė” ė¬“ź· ģķģģ ģ ģ”°ėė©°, ė¤ėØź³ ģ ģ ģ HPLCė„¼ ķµķ“ ā„99% ģėė„¼ ė³“ģ„ķ©ėė¤.
ķģ§ źø°ģ¤:
- ģė (HPLC): ā„99%
- ģėķ”ģ ģģ¤: <0.1 EU/mg
- ģė¶ ķØė: <6%
- ģ©ķ“ė: ė©øź· ģ¦ė„ģ, ķ¬ģ ģģøķøģ°, ėė DMSOģ ģ©ķ“ ź°ė„
- ģøź“: ė°±ģ ėź²°ź±“ģ”° ė¶ė§
- ė³“ź“ ģØė: ā20āÆĀ°C (ģ„źø° ė³“ź“ ģ)
ėŖØė ģ ķģė COA(ģķģ±ģ ģ), ģ ģ”°ė²ķø, ģ ķµźø°ķ, HPLC ė¶ģ ģ ė³“ź° ķ¬ķØė©ėė¤.
š HPLC ė¶ģ ģģ½
ź° ė”ķøė ė¤ģź³¼ ź°ģ HPLC ė¶ģģ ķµķ“ ģ¼ź“ģ±ź³¼ ģģ ģ±ģ ķģøķ©ėė¤:
| ķėŖ© | ź° |
|---|---|
| ģ ģ§ ģź° | 5.24ė¶ |
| ķ¼ķ¬ ģė | ā„99.03% |
| ź²ģ¶ė ė¶ģė¬¼ | <0.5% |
| ź°ģ§ ķģ„ | 220 nm |
ģ“ ė¶ģģ ģ¤ķ ź²°ź³¼ģ ģ¬ķģ±ź³¼ ģ ė¢°ģ±ģ ė³“ģ„ķ©ėė¤.
š§Ŗ ģ¬źµ¬ģ± ė° ė³“ź“ ģ§ģ¹Ø
ģ¬źµ¬ģ±:
ė©øź· ģ¦ė„ģ, 0.9% ģė¦¬ģģ¼ģ, ėė PBS ė± ģģ¶© ģ©ģ”ģ ė
¹ģ¬ ģ¬ģ©ķė©°, ģ¤ķ ėŖ©ģ ģ ė§ź² ėėė„¼ ģ”°ģ ķ©ėė¤.
ė³“ź“:
- ėź²°ź±“ģ”° ģķ: ā20āÆĀ°Cģģ 24ź°ģ ģ“ģ ģģ
- ģ¬źµ¬ģ± ķ: 2ā8āÆĀ°Cģģ ė³“ź“ķź³ 7ā14ģ¼ ģ“ė“ ģ¬ģ©
- ģ¬ėė/ģ¬ķ“ėģ ķ¼ķ“ģ¼ ķØ
š¦ ķ¬ģ„ ģµģ
HPSė ė¤ģ ģ©ėģ¼ė” DSIPė„¼ ģ ź³µķ©ėė¤:
- 1 mg
- 2 mg
- 5 mg
- ėė ģ£¼ė¬ø ėė ė§ģ¶¤ķ ķ¬ģ„ ź°ė„ (ģģ² ģ)
ėŖØė ė°ģ“ģģ ģ§ģ ķė¬ģ(Nitrogen-flushed) ģķė” ģ§ź³µ ė°ė“ėė©°, ź“ ģ°ØėØ ģ²ė¦¬ė” ģģ ģ±ģ“ ģ ģ§ė©ėė¤.
ā ļø ė²ģ ź³ ģ§ ė° ģģ ģ§ģ¹Ø
ģ“ ģ ķģ ģ¤ģ§ ģ¤ķģ¤ ģ°źµ¬ ģ ģ©ģ ėė¤. ģøź° ėė ėė¬¼ģ ģ§ėØ, ģ¹ė£ ėė ģė¹ ėŖ©ģ ģ¼ė” ģ¬ģ©ķ“ģė ģ ė©ėė¤. ģ¬ģ© ģ§ģ¹Øģ ė²ģ“ė ķģ©ģ ė²ģ ģ± ģģ“ ė°ė„¼ ģ ģģµėė¤.
ģ¤ķ ģ ģģ ė³“ķøźµ¬(PPE) ģ°©ģ© ķģ ā ģ„ź°, ģ¤ķė³µ, ė³“ķø ģź²½. ģ ė¬ø ģøė „ģ ź°ė ķģ ģøģ¦ė ģ¤ķ ķź²½ģģė§ ģ¬ģ©ķ“ģ¼ ķ©ėė¤.
š ģ HPSė„¼ ģ ķķ“ģ¼ ķ ź¹ģ?
**HPS (High Purity Science)**ė ģ ģøź³ ģė§ģ ģ°źµ¬ źø°ź“ź³¼ ė°ģ“ģ¤ķ ķ¬ źø°ģ ģ“ ģ ė¢°ķė ķ©ķģ“ė ź³µźøģ ģ²“ģ ėė¤:
- ISO 9001:2015 ģøģ¦ė ģ ģ”° ź³µģ
- COA, HPLC, MS ķ¬ķØķ ģģ ķ ė¶ģ ė¬øģ ģ ź³µ
- ķ¬ėŖ ķ ź³µźøė§ ė° źø°ģ ģ§ģ
- ė§ģ¶¤ķ ķ©ķģ“ė ķ©ģ± ģė¹ģ¤ ģ ź³µ
HPSė ź³ ķģ§, ģ¼ź“ģ±, ź²½ģė „ ģė ź°ź²©ģ¼ė” ģ ģøź³ ź³¼ķģė¤ģź² ģ ķė°ź³ ģģµėė¤.
š ź²°ė”
**DSIP (Delta Sleep-Inducing Peptide)**ė ģ ź²½ź³¼ķ, ė“ė¶ė¹ķ, ģė©“ ź³¼ķ ė¶ģ¼ģģ ģ¤ģķ ģ°źµ¬ ėźµ¬ģ ėė¤. HPSģģ ģ ģ”°ķ DSIPė ā„99% ģėģ HPLC ģøģ¦ ģ ķģ¼ė”, ė¤ģķ ģ ģģ ėŖØėøģģ ķģķ ģ¤ķ ģ¬ķģ±ģ ė³“ģ„ķ©ėė¤.
ģź²©ķ ķģ§ źø°ģ¤ź³¼ ģ ė¢°ķ ģ ģė ģģ° ģģ¤ķ ģ ė°ķģ¼ė”, HPSė ģģ ģ±, ģė, ģ°źµ¬ ķØģØģ±ģ ėŖØė ė§ģ”±ģķ¤ė ģ¤ķģ© DSIPė„¼ ģ ź³µķ©ėė¤.
DSIPļ¼ćć«ćæē”ē čŖå°ććććļ¼ā é«ē“åŗ¦ē ē©¶ēØććććļ¼ā„99% HPLCļ¼ā č£½é å ļ¼HPS
š§Ŗ č£½åę¦č¦
- č£½ååļ¼ DSIPļ¼Delta Sleep-Inducing Peptideļ¼
- CASēŖå·ļ¼ 62568-57-4
- ååå¼ļ¼ Cāā HāāNāāOāā
- ååéļ¼ 848.81 g/mol
- ć¢ććé øé åļ¼ Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- å„åļ¼ ćć«ćæē”ē čŖå°ćććććDSIPćććć
- č£½é č ļ¼ HPSļ¼High Purity Scienceļ¼
- ē“åŗ¦ļ¼ ā„99%ļ¼é«ę§č½ę¶²ä½ćÆćććć°ć©ćć£ć¼ļ¼HPLCļ¼ć«ććę¤čؼļ¼
- å½¢ē¶ļ¼ ē½č²ć®åēµä¹¾ē„ē²ę«
- å č£ ļ¼ å»č¬åć°ć¬ć¼ćć®ē ē©¶ēØćć¤ć¢ć«
- ēØéļ¼ ē ē©¶ēØéć®ćæć«éå®ļ¼äŗŗć¾ććÆåē©ćøć®ä½æēØćÆē¦ę¢ļ¼
š¬ DSIPćØćÆļ¼
DSIPļ¼ćć«ćæē”ē čŖå°ććććļ¼ ćÆć1977幓ć«ć¦ćµć®ć®č³ććåćć¦åé¢ććć天ē¶ć®ē„ēµććććć§ććē”ē čŖæēÆćēē©å¦ēćŖćŗć ćē„ēµå åę³čŖæēÆćøć®é¢äøćåŗćē ē©¶ććć¦ćć¾ćć9åć®ć¢ććé øćććŖćććććććć§ćććē„ēµčŖæēÆć»ēēčŖæēÆć®ę©č½ćęć£ć¦ćć¾ćć
HPSē¤¾č£½ć®åęDSIPćÆćå³ę ¼ćŖē ē©¶ē°å¢ć®äøć§č£½é ćććHPLCć«ćć99%仄äøć®ē“åŗ¦ćäæčؼććć¦ćć¾ććēēå¦ēć»ē„ēµēē©å¦ēē ē©¶ć«ććć¦é«ćåē¾ę§ćØäæ”é ¼ę§ćęä¾ćć¾ćć
ā äø»ćŖē¹é·
- é«ē“åŗ¦ļ¼ā„99%ļ¼ ā HPLCć«ććę¤čؼęø
- å»č¬åć°ć¬ć¼ćć®åēµä¹¾ē„ ā é·ęäæåć«ęé©
- äæ”é ¼ę§ć®é«ćč£½é å ā HPSļ¼ē ē©¶ēØććććć®å°éć”ć¼ć«ć¼ļ¼
- å³ę ¼ćŖåč³Ŗē®”ēćØćććčæ½č·”
- ē ē©¶å°ēØļ¼in vitroććć³åčØåŗēØéļ¼
š§ ēēå¦ēęē¾©
1. ē”ē čŖæēÆ
DSIPćÆć**å¾ę³¢ē”ē ļ¼SWSļ¼**ćčŖå°ććä½ēØć§ē„ćććREMē”ē ć«ćÆå½±éæćäøćć¾ćććć»ćććć³ććć«ć¢ćć¬ććŖć³ćŖć©ć®ē„ēµä¼éē©č³Ŗć®ę¾åŗć«é¢äøćććØčćććć¦ćć¾ćć
2. å åę³čŖæēÆ
仄äøć®ćć«ć¢ć³åę³ć«é¢äøććåÆč½ę§ćććć¾ćļ¼
- åÆč ē®č³Ŗåŗęæćć«ć¢ć³ļ¼ACTHļ¼
- é»ä½å½¢ęćć«ć¢ć³ļ¼LHļ¼
- ęé·ćć«ć¢ć³ļ¼GHļ¼
č¦åŗäøéØāäøåä½ē³»ć®čŖæēÆć«é¢é£ććåÆč½ę§ćććć¾ćć
3. ć¹ćć¬ć¹åæēć®ē·©å
åē©ć¢ćć«ć«ććć¦ćDSIPćÆć³ć«ćć³ć¹ććć³ć®ć¬ćć«ćä½äøćććäøå®ęå¶ä½ēØļ¼ć¢ć³ćć·ćŖćŖćć£ććÆļ¼ćć¹ćć¬ć¹ē·©åå¹ęćē¤ŗćć¦ćć¾ćććććÆGABAä½åē³»ćć»ćććć³ē³»ć®čŖæēÆćØé¢é£ćć¦ććåÆč½ę§ćććć¾ćć
4. ē¼ēē„č¦ć®čŖæę“
ćŖććŖć¤ćå容ä½ē³»ć«ä½ēØććēč¦é¾å¤ć«å½±éæćäøććåÆč½ę§ćććć¾ćć
5. ä½ęø©čŖæēÆćØćµć¼ć«ćć£ć¢ć³ćŖćŗć
DSIPćÆä½ęø©ćēä½ćŖćŗć ć«ćå½±éæćäøćććØčćććć**ęéēē©å¦ļ¼ćÆćććć¤ćŖććøć¼ļ¼ćęéēę³ļ¼ćÆććć»ć©ćć¼ļ¼**ć«ćććē ē©¶åÆ¾č±”ćØćŖć£ć¦ćć¾ćć
š ē ē©¶ēØéćØåæēØé å
| ē ē©¶åé | åæēØä¾ |
|---|---|
| ē„ēµē§å¦ | ē”ē åØęćē„ēµä¼éćē¼ēčŖæēÆ |
| å åę³å¦ | ćć«ć¢ć³åę³ćęé·ćć«ć¢ć³ē ē©¶ |
| ē²¾ē„č¬ēå¦ | ć¹ćć¬ć¹ćäøå®ććć¤ć¢ćć« |
| ęéēē©å¦ | ćµć¼ć«ćć£ć¢ć³ćŖćŗć ćēä½ęčØē ē©¶ |
| å ē«å¦ | å ē«åæēććµć¤ćć«ć¤ć³ć®čŖæēÆ |
| 代č¬ē ē©¶ | 代č¬ēććØćć«ć®ć¼ćć”ćŖć¹ćæć·ć¹ć®é¢äø |
š č£½é ćØåč³Ŗē®”ēļ¼HPSć«ććļ¼
**HPSļ¼High Purity Scienceļ¼**ćÆćGMPļ¼é©ę£č£½é åŗęŗļ¼ć«ęŗę ćć**åŗēøććććåęļ¼SPPSļ¼**ę³ć«ććDSIPćč£½é ćć¦ćć¾ćććć¹ć¦ć®ććććÆē”čćć¤ęø©åŗ¦ē®”ēćććē°å¢äøć§ēē£ćććHPLCć«ććē“åŗ¦ę¤ę»ćč”ććć¾ćć
åč³Ŗē®”ēé ē®ļ¼
- HPLCē“åŗ¦ļ¼ ā„99%
- ćØć³ćććć·ć³ęæåŗ¦ļ¼ <0.1 EU/mg
- ę°“åå«ęéļ¼ <6%
- ęŗ¶č§£ę§ļ¼ ē²¾č£½ę°“ćåøé ¢é øćć¾ććÆDMSOć«åÆęŗ¶
- å¤č¦³ļ¼ ē½č²åēµä¹¾ē„ćć¦ćć¼
- äæåęø©åŗ¦ļ¼ ā20Ā°Cļ¼é·ęäæåļ¼
č£½åć«ćÆćć¹ć¦ć**åęčؼęęøļ¼COAļ¼**ćä»å±ćććććēŖå·ć»ęå¹ęéć»HPLCåęę å ±ćčØč¼ććć¦ćć¾ćć
š HPLCåęćµććŖć¼
| åęé ē® | å¤ |
|---|---|
| äæęęé | 5.24å |
| ćć¼ćÆē“åŗ¦ | ā„99.03% |
| ę¤åŗćććäøē“ē© | <0.5% |
| ę¤åŗę³¢é· | 220 nm |
HPLCåęćÆć試éØć®åē¾ę§ć»äæ”é ¼ę§ćęÆććéč¦ćŖęęØć§ćć
š§ ęŗ¶č§£ććć³äæåę¹ę³
ęŗ¶č§£ę¹ę³ļ¼
ę»
čē²¾č£½ę°“ć0.9%ēēé£å”©ę°“ćPBSćŖć©ć®ćććć”ć¼ć§åę§ęćēØéć«åæćć¦ęæåŗ¦ćčŖæę“ćć¦ćć ććć
äæåę”件ļ¼
- åēµä¹¾ē„ē¶ę ļ¼ ā20Ā°Cć§24ć¶ę仄äøå®å®
- åę§ęå¾ļ¼ 2ļ½8Ā°Cć§äæåćć7ć14ę„仄å ć«ä½æēØ
- ååēµć»åč§£åćÆéæććććØ
š¦ ććć±ć¼ćøćŖćć·ć§ć³
仄äøć®å®¹éć§ęä¾åÆč½ļ¼
- 1mg ćć¤ć¢ć«
- 2mg ćć¤ć¢ć«
- 5mg ćć¤ć¢ć«
- 大å£ę³Øęćć«ć¹ćæć ććć±ć¼ćøćåƾåæåÆč½ļ¼č¦ēøč«ļ¼
ćć¹ć¦ć®ćć¤ć¢ć«ćÆćēŖē“ ē½®ęć»ēē©ŗåÆå°ć»é®å å¦ēęøćæ容åØć§åŗč·ćććåč³Ŗćę大éäæęćć¾ćć
ā ļø ę³ēę³Øęć»å®å Øć«é¢ććę å ±
ćć®č£½åćÆē ē©¶ēØéć®ćæć«ä½æēØåÆč½ć§ććčØŗęć»ę²»ēć»ććć¾ććÆåē©ćøć®ęäøć«ćÆä½æēØć§ćć¾ćććē ē©¶ęéćč¶ ććäøę£ä½æēØć«ćÆę³ēč²¬ä»»ćēććåÆč½ę§ćććć¾ćć
åäŗŗēØäæč·å ·ļ¼PPEļ¼ļ¼ęč¢ćå®éØēØē½č”£ćäæč·ć”ć¬ććŖć©ļ¼ćēēØććčŖåÆćććē ē©¶ę½čØå ć§ćé©åćŖē£ē£ć®ććØåćę±ć£ć¦ćć ććć
š HPSćéøć¶ēē±
**HPSļ¼High Purity Scienceļ¼**ćÆćäøēäøć®ē ē©¶ę©é¢ć»å¤§å¦ć»č£½č¬ä¼ē¤¾ććäæ”é ¼ććć¦ććććććć”ć¼ć«ć¼ć§ćļ¼
- ISO 9001:2015 čŖčؼåå¾ęø
- HPLCć»MSć»COAćå«ćå®å ØćŖåęęøé”ä»ć
- ćć¬ć¼ćµććŖćć£ćØéęę§ć®é«ćč£½é
- ćŖć¼ćć¼ć”ć¤ćć®ććććéēŗć«ćåƾåæ
åē¾ę§ćåč³Ŗćć³ć¹ćććć©ć¼ćć³ć¹ćéč¦ććē ē©¶č ć«ęé©ćŖćć¼ććć¼ć§ćć
š ēµč«
**DSIPļ¼ćć«ćæē”ē čŖå°ććććļ¼**ćÆćē„ēµē§å¦ć»å åę³å¦ć»ē”ē ē ē©¶ć«ććć¦å¤§ććŖē ē©¶ä¾”å¤ćęć¤ććććć§ććHPSć®é«ē“åŗ¦DSIPļ¼ā„99% HPLCļ¼ćÆćåčØåŗć¢ćć«ć§ć®äæ”é ¼ę§ćØåē¾ę§ćęä¾ćć¾ćć
åč³Ŗćøć®ćć ćććØå®å ØćŖåęćµćć¼ććåććHPSć®DSIPćÆćē ē©¶ēØéć«ćććęčÆć®éøęč¢ć§ćć
OUR ADVANTAGES
24x7 CUSTOMER SUPPORT
OUR WAREHOUSES are in Europe, USA, SINGAPORE, VIETNAM, THAILAND, UK, MALAYSIA
24×7 online customer servicesĀ
HPLC and MS records for all of our products
The R&D center in the USA
OVER two decades experience in chemical and peptide industry
Producing as OEM /ODM with our customer labels
Accepting different currencies
98.3% customer satisfaction in two decades
Our delivery solutions are as follow:
– Via Express services such as FedEx, EMS, DHL, TNT, USPS priority, UPS
– E-Commerce post service from the USA , Europe, Hongkong
– International Air freights for heavy packages over 50kg
– International ocean and rail freight for heavy packages over 200kg
++OVER 5000 M2 LAB & Facility++
We provide high-quality peptide synthesis service with a 99%Ā peptide synthesis success rate, which is well above the industry standard of 75%. We are committed toĀ Total Quality Management (TQM)Ā to ensure our customersā complete satisfaction. TQM includes MS and HPLC analyses performed after the completion of peptide synthesis, purification, and QC (quality control) steps. These analyses are followed by independent QA (quality assurance) procedures, which double guarantee the highest quality possible for every delivered peptide.
@@CONTACT US: @@
Learn more about our laboratory standards on the HPS (HONGKONG PEPTIDE SCIENCES peptides homepage.
1 review for DSIP 10mg
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Karen Anderson –
Reliable Peptide Supplier
Great experience purchasing peptides from them. Good quality, high purity, fair pricing, and professional service. Communication was smooth, packaging was secure, and the whole process felt trustworthy. A solid supplier Iām comfortable continuing to work with and recommending to others.