LL-37 – Antimicrobial Peptide for Innate Immunity & Inflammation Research

LL-37 is a human cathelicidin-derived antimicrobial peptide widely used in laboratory and preclinical research to study innate immune responses, host defense mechanisms, and inflammatory signaling. As the only known human cathelicidin, this peptide plays a critical role in immune modulation and microbial interaction studies.

This product is supplied for laboratory research use only and is not intended for human or animal consumption, therapeutic use, or diagnostic applications.

Overview

LL-37 is generated from the precursor protein hCAP-18 and is recognized for its broad-spectrum antimicrobial activityas well as its ability to influence immune cell signaling. In research environments, it is commonly applied to investigate host–pathogen interactions, immune regulation, and inflammatory pathways.

Its amphipathic structure makes this peptide particularly useful in membrane interaction and peptide–lipid studies.

Biological Role (Research Context)

In controlled laboratory studies, this antimicrobial peptide has been shown to:

• Interact with bacterial and viral membranes
• Modulate cytokine and chemokine signaling
• Influence innate immune cell activation
• Participate in inflammatory and wound-response pathways
• Serve as a model peptide for host defense research

These properties make it a valuable tool in immunology and microbiology research.

Key Research Applications

LL-37 is frequently used in:

• Innate immunity and host defense studies
• Antimicrobial mechanism research
• Inflammation and immune signaling models
• Host–pathogen interaction experiments
• Peptide–membrane interaction studies

Its well-characterized sequence supports reproducible in vitro and preclinical experiments.

Product Specifications

• Name: LL-37
• Peptide Class: Human cathelicidin (antimicrobial peptide)
• Sequence Length: 37 amino acids
• Purity: ≥98–99% (HPLC-verified)
• Form: Lyophilized powder
• Appearance: White to off-white solid
• Solubility: Sterile water, PBS, or mild buffers (research use only)

Storage & Handling

• Store at -20°C or below
• Reconstitute under sterile laboratory conditions
• Aliquot after reconstitution to avoid repeated freeze–thaw cycles
• Follow standard peptide-handling protocols

Research Use Disclaimer

This peptide is provided exclusively for laboratory research purposes.
It is not approved for human or animal use, and is not intended for therapeutic, diagnostic, or cosmetic applications.

Yoast-Friendly Meta Description

High-purity LL-37 for laboratory research. Used in innate immunity, antimicrobial activity, and inflammation studies.