PNC27, PNC-27, PNC 27

PNC-27 Peptide – Product Description (For Laboratory Research Use Only)

PNC-27 is a synthetic peptide derived from the p53 tumor suppressor protein, engineered for in-vitro and preclinical research focused on membrane interactions, cancer cell biology, and peptide–lipid binding mechanisms. It is widely studied for its selective affinity to HDM-2 (MDM2)–expressing cell membranes, making it a valuable research tool in oncology and molecular biology laboratories.

Overview

PNC-27 is designed to combine a p53-derived sequence with a membrane-penetrating domain, allowing researchers to investigate how p53-related peptides interact with cancer cell membranes at a molecular level. Unlike traditional cytotoxic compounds, PNC-27 is studied specifically for its targeted membrane disruption behavior in cells overexpressing HDM-2, a protein frequently upregulated in malignant cells.

Key Research Characteristics

• p53-Derived Structure: Based on amino acid sequences from the p53 tumor suppressor, a critical protein in cell cycle regulation and apoptosis research.
• HDM-2 Interaction Studies: Commonly used to study the role of HDM-2 in cancer cell survival and membrane integrity.
• Membrane Activity Research: Investigated for its ability to form pores in lipid membranes under controlled laboratory conditions.
• Selective Cellular Interaction: Demonstrates preferential binding in experimental models involving malignant vs. non-malignant cells, making it useful for selectivity studies.

Common Research Applications

PNC-27 is frequently utilized in:

• Cancer cell line studies (in vitro)
• Membrane pore-formation and lipid bilayer research
• Peptide–protein interaction assays
• Apoptosis and necrosis pathway investigations
• HDM-2 / p53 pathway modeling
• Comparative cytotoxicity studies under laboratory conditions

Peptide Specifications

• Peptide Name: PNC-27
• Peptide Class: p53-derived research peptide
• Form: Lyophilized powder
• Purity: Typically ≥99% (HPLC-verified, depending on supplier)
• Appearance: White to off-white lyophilized solid
• Solubility: Soluble in sterile water, PBS, or DMSO (research protocols may vary)

Handling & Storage

• Store lyophilized PNC-27 at -20°C or below for long-term stability
• After reconstitution, aliquot and store according to laboratory best practices
• Avoid repeated freeze–thaw cycles
• Handle using appropriate laboratory PPE and sterile techniques

Research Advantages

• Enables high-specificity mechanistic studies related to cancer cell membranes
• Useful for advanced peptide research beyond small-molecule models
• Supports exploratory work on targeted membrane disruption strategies
• Complements broader p53 and HDM-2 pathway research programs

Important Notice

PNC-27 is for laboratory research use only.
Not for human or animal consumption, diagnostic use, or therapeutic application.
All research involving this peptide must be conducted by qualified professionals in properly equipped research facilities and in compliance with local regulations.